Table 4 Risk of SPC according to treatment for primary BC (1993–2013)
RT | Non-RT | Surgery | Non-Surgery | Chemotherapy | Non-chemotherapy | |
|---|---|---|---|---|---|---|
SIR | SIR | SIR | SIR | SIR | SIR | |
All SPCs | 1.01 | 0.93# | 0.94# | 0.85# | 0.94 | 0.93# |
All SPCs excluding BC, KC, pelvic and ureteral cancers | 1.04 | 0.96# | 0.97# | 0.86# | 0.94 | 0.96# |
Buccal cavity, pharynx | 0 | 0.80 | 0.83 | 0.35 | 0.56 | 0.82 |
Tongue | 0 | 0.37# | 0.40 | 0 | 0.86 | 0.31# |
Salivary gland | 0 | 0.94 | 1.01 | 0 | 0 | 1.03 |
Tonsil | 0 | 0.28 | 0.30 | 0 | 0 | 0.31 |
Hypopharynx | 0 | 1.21 | 1.30 | 0 | 0.59 | 1.26 |
Digestive system | 0.88 | 0.85# | 0.87# | 0.66# | 0.78# | 0.86# |
Esophagus | 0.60 | 0.98 | 0.97 | 0.95 | 0.86 | 0.98 |
Stomach | 0.59 | 0.80# | 0.81# | 0.64# | 0.71# | 0.80# |
Small intestine | 4.18 | 1.38 | 1.49 | 0.79 | 0.68 | 1.51 |
Colon | 1.35 | 0.83# | 0.89# | 0.39# | 1.04 | 0.82# |
Rectum, rectosigmoid junction | 1.20 | 0.91 | 0.91 | 0.90 | 0.87 | 0.92 |
Anus, anal canal | 0 | 0.99 | 0.86 | 1.98 | 1.86 | 0.87 |
Liver | 0.98 | 0.79# | 0.80# | 0.70 | 0.73 | 0.80# |
Gallbladder | 0 | 0.79 | 0.78 | 0.74 | 0.17# | 0.84 |
Bile ducts, other biliary | 0.64 | 0.92 | 0.96 | 0.53 | 0.91 | 0.92 |
Pancreas | 1.4 | 0.97 | 1.01 | 0.69 | 0.62 | 1.02 |
Respiratory system | 1.16 | 1.05 | 1.05 | 1.01 | 0.98 | 1.06 |
Nose, nasal cavity, ear | 7.75 | 0.95 | 1.17 | 0 | 1.25 | 1.04 |
Larynx | 0 | 1.22 | 1.13 | 1.90 | 0.95 | 1.23 |
Lung, bronchus | 1.18 | 1.04 | 1.05 | 0.97 | 0.98 | 1.05 |
Female breast | 0 | 1.14 | 1.20 | 0.34 | 0.62 | 1.18 |
Female genital system | 1.50 | 1.09 | 1.12 | 0.93 | 1.86 | 1.01 |
Male genital system | 2.23# | 1.44# | 1.43# | 1.74# | 1.85# | 1.41# |
Prostate | 2.28# | 1.44# | 1.43# | 1.70# | 1.83# | 1.41# |
Testis | 0 | 4.02 | 4.32 | 0 | 12.33 | 2.95 |
Urinary system | 1.03 | 0.73# | 0.69# | 1.1 | 1.28 | 0.67# |
Urinary bladder | 0 | 0.46# | 0.43# | 0.61 | 1.03 | 0.38# |
Kidney parenchyma | 2.81 | 1.45# | 1.40# | 2.29# | 1.98# | 1.41# |
Renal pelvis, other urinary | 2.43 | 0.24# | 0.22# | 0.90 | 0.78 | 0.22# |
Brain, central nervous system | 0 | 0.77 | 0.78 | 0.54 | 0 | 0.85 |
Thyroid | 0 | 1.23# | 1.23# | 1 | 1.65 | 1.16 |
Lymphatic, hematopoietic | 0.46 | 0.76# | 0.76# | 0.61 | 0.52 | 0.78# |
Hodgkin lymphoma | 0 | 0.79 | 0.84 | 0 | 3.65 | 0.43 |
Non-Hodgkin lymphoma | 0 | 0.70# | 0.71# | 0.50 | 0.42 | 0.72# |
Myeloma | 0 | 0.83 | 0.80 | 1.01 | 1.66 | 0.72 |
Leukemia | 1.53 | 0.81 | 0.85 | 0.58 | 0.00# | 0.92 |