Skip to main content

Table 4 Risk of SPC according to treatment for primary BC (1993–2013)

From: Risk of second primary Cancer among bladder Cancer patients: a population-based cohort study in Korea

  RT Non-RT Surgery Non-Surgery Chemotherapy Non-chemotherapy
  SIR SIR SIR SIR SIR SIR
All SPCs 1.01 0.93# 0.94# 0.85# 0.94 0.93#
All SPCs excluding BC, KC, pelvic and ureteral cancers 1.04 0.96# 0.97# 0.86# 0.94 0.96#
Buccal cavity, pharynx 0 0.80 0.83 0.35 0.56 0.82
Tongue 0 0.37# 0.40 0 0.86 0.31#
Salivary gland 0 0.94 1.01 0 0 1.03
Tonsil 0 0.28 0.30 0 0 0.31
Hypopharynx 0 1.21 1.30 0 0.59 1.26
Digestive system 0.88 0.85# 0.87# 0.66# 0.78# 0.86#
Esophagus 0.60 0.98 0.97 0.95 0.86 0.98
Stomach 0.59 0.80# 0.81# 0.64# 0.71# 0.80#
Small intestine 4.18 1.38 1.49 0.79 0.68 1.51
Colon 1.35 0.83# 0.89# 0.39# 1.04 0.82#
Rectum, rectosigmoid junction 1.20 0.91 0.91 0.90 0.87 0.92
Anus, anal canal 0 0.99 0.86 1.98 1.86 0.87
Liver 0.98 0.79# 0.80# 0.70 0.73 0.80#
Gallbladder 0 0.79 0.78 0.74 0.17# 0.84
Bile ducts, other biliary 0.64 0.92 0.96 0.53 0.91 0.92
Pancreas 1.4 0.97 1.01 0.69 0.62 1.02
Respiratory system 1.16 1.05 1.05 1.01 0.98 1.06
Nose, nasal cavity, ear 7.75 0.95 1.17 0 1.25 1.04
Larynx 0 1.22 1.13 1.90 0.95 1.23
Lung, bronchus 1.18 1.04 1.05 0.97 0.98 1.05
Female breast 0 1.14 1.20 0.34 0.62 1.18
Female genital system 1.50 1.09 1.12 0.93 1.86 1.01
Male genital system 2.23# 1.44# 1.43# 1.74# 1.85# 1.41#
Prostate 2.28# 1.44# 1.43# 1.70# 1.83# 1.41#
Testis 0 4.02 4.32 0 12.33 2.95
Urinary system 1.03 0.73# 0.69# 1.1 1.28 0.67#
Urinary bladder 0 0.46# 0.43# 0.61 1.03 0.38#
Kidney parenchyma 2.81 1.45# 1.40# 2.29# 1.98# 1.41#
Renal pelvis, other urinary 2.43 0.24# 0.22# 0.90 0.78 0.22#
Brain, central nervous system 0 0.77 0.78 0.54 0 0.85
Thyroid 0 1.23# 1.23# 1 1.65 1.16
Lymphatic, hematopoietic 0.46 0.76# 0.76# 0.61 0.52 0.78#
Hodgkin lymphoma 0 0.79 0.84 0 3.65 0.43
Non-Hodgkin lymphoma 0 0.70# 0.71# 0.50 0.42 0.72#
Myeloma 0 0.83 0.80 1.01 1.66 0.72
Leukemia 1.53 0.81 0.85 0.58 0.00# 0.92
  1. SIR, standardized incidence ratio, RT: radiotherapy, BC: bladder cancer, SPC: second primary cancer,
  2. KC: kidney cancer, # significant at alpha = 0.05