MicroRNA-29b-2-5p inhibits cell proliferation by directly targeting Cbl-b in pancreatic ductal adenocarcinoma

BMC Cancer

Table 2 Multivariate Cox regression analysis including miR-29b-2-5p expression levels and overall survival in 100 patients with PDAC

Variables	Univariable analysis			Multivariable analysis
Variables	HR	95% CI	P value	HR	95% CI	P value
miR-29b-5p(high/low)	0.503	0.32–0.788	0.003	0.492	0.300–0.807	0.005
pT category(T4/T3/T2/T1)	1.212	0975–1.508	0.084	1.286	1.004–1.646	0.046
pN category(N1/N0)	1.871	1.147–3.053	0.012
CA 19-9(≥ 37 U/mL/<37 U/mL)	3.315	1.426–7.706	0.005	3.47	1.484–8.112	0.004
Tumor Differenciation (Poor/Moderately/Well)	1.45	1.014–2.074	0.042	1.472	1.016–2.133	0.041

The multivariate Cox proportional hazards model (forward) was fitted using all of the clinical and pathological variables, which included age (≥60 vs. <60 years old), gender (male vs. female), type of operation (pancreaticoduodenectomy vs. distal pancreatectomy vs. total pancreatectomy), surgical margins (positive vs. negative), location of tumor (head vs. body or tail), maximal tumor diameter, histological differentiation (poorly vs. moderately vs. well differentiated), pT category (pT4 vs. pT3 vs. pT2 vs. pT1), pN category (pN1 vs. pN0), vessel invasion (yes vs. no), vascular tumor thrombus (yes vs. no), adjacent organs invasion (yes vs. no), pTNM category (I vs. II vs. III), miR-29b-2-5p expression (high expression vs. low expression), and CA19–9 level (≥37 U/mL vs. < 37 U/mL)

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