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Fig. 2 | BMC Cancer

Fig. 2

From: MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB

Fig. 2

Deletion of MAP3K7/CASP8AP2 does not affect outcome of pediatric T-ALL patients. Cumulative incidence of relapse (pCIR) and probability of event-free survival (pEFS) for T-ALL patients enrolled in ALL-BFM 2000 and ALL-BFM 2009 with MAP3K7/CASP8AP2 wild type (blue) or MAP3K7/CASP8AP2 deletion (red). Results are presented as estimated probability of 5-year EFS (pEFS) and estimated cumulative incidence of relapse (pCIR) with standard error (± SE). a T-ALL patients with or without MAP3K7/CASP8AP2 deletion (n = 327). MAP3K7/CASP8AP2 deletion neither affects the pEFS (p(Log-Rank) = 0.4) nor pCIR (p(Gray) = 0.98). b T-ALL patients with SIL-TAL1 fusion (n = 52) who do or do not carry an additional MAP3K7/CASP8AP2 deletion. SIL-TAL1 positive patients harboring a deletion of MAP3K7/CASP8AP2 show a trend towards a higher pCIR (p(Gray) = 0.13)

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BMC Cancer

ISSN: 1471-2407

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