Fig. 1
Regions of minimal deletion (RMD) on chr6q in pediatric acute lymphoblastic leukemia (ALL) and/or T-cell lymphoblastic lymphoma (T-LBL) as identified in published studies since 2004. The RMD results were derived from array comparative genomic hybridization (CGH)1, loss of heterozygosity analysis (LOH)2, single nucleotide polymorphism array analysis (SNP array)3 and fluorescence in situ hybridization (FISH)4. Originally described nucleotide positions of the proximal and distal boundaries of each RMD were adjusted to the current reference genome GRCh38/hg38 (released in 12/2013). Relative positions of previously suggested potential tumor suppressor genes (EPHA7, GRIK2) and CASP8AP2/MAP3K7 are shown by dashed lines. A RMD derived from studies of pediatric B- and/or T-ALL samples. B RMD derived from studies in T-LBL