Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial

Table 4 Univariate and multivariate analyses for determinants of overall survival

Parameters	Univariate analysis	Multivariate analysis
Parameters	P value	Hazard ratio	95% CI	P value
Age (< 65/≥65 years)	0.304
Gender (Male/Female)	0.325
ECOG performance status (0/1)	0.187
Platelet count (< 14.9 × 10⁴/> 14.9 × 10⁴ /μL)	0.07
Child-Pugh score (A/B)	0.008
Diameter of main tumor(< 80 mm/≥ 80 mm)	0.036
Macroscopic vascular invasion (without/with)	0.646
TACE refractory (without/with)	0.101
AFP (< 1895/≥ 1895 ng /mL)	0.515
DCP (< 3854/≥ 3854 mAU/mL)	0.055
Extrahepatic spread (without/with)	0.004	3.905	1.420–10.736	0.008

Abbreviations: AFP alpha-fetoprotein, DCP des-gamma-carboxy prothrombin, ECOG Eastern Cooperative Oncology Group, MVI macroscopic vascular invasion, TACE transarterial chemoembolization

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