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Table 4 Univariate and multivariate analyses for determinants of overall survival

From: Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial

Parameters Univariate analysis Multivariate analysis
P value Hazard ratio 95% CI P value
Age (< 65/≥65 years) 0.304    
Gender (Male/Female) 0.325    
ECOG performance status (0/1) 0.187    
Platelet count (<  14.9 × 104/>  14.9 × 104 /μL) 0.07    
Child-Pugh score (A/B) 0.008    
Diameter of main tumor(<  80 mm/≥ 80 mm) 0.036    
Macroscopic vascular invasion (without/with) 0.646    
TACE refractory (without/with) 0.101    
AFP (<  1895/≥ 1895 ng /mL) 0.515    
DCP (<  3854/≥ 3854 mAU/mL) 0.055    
Extrahepatic spread (without/with) 0.004 3.905 1.420–10.736 0.008
  1. Abbreviations: AFP alpha-fetoprotein, DCP des-gamma-carboxy prothrombin, ECOG Eastern Cooperative Oncology Group, MVI macroscopic vascular invasion, TACE transarterial chemoembolization