|
Variable
|
levels
|
Mitotic count per 2 mm2
|
CCND1 copy number ratiob
|
|---|
|
< 8 / 2 mm2
|
≥ 8 / 2 mm2
| |
< 0
|
> 0
| |
|---|
|
N (%)
|
N (%)
|
p valuea
|
N (%)
|
N (%)
|
p valuea
|
|---|
|
Age
|
< 65
|
133 (47)
|
133 (49)
|
0.72
|
101 (49)
|
129 (48)
|
0.72
|
| |
≥ 65
|
150 (53)
|
141 (51)
| |
104 (51)
|
142 (52)
| |
|
Nodal status
|
negative
|
173 (61)
|
135 (49)
|
0.005
|
112 (55)
|
152 (56)
|
0.75
|
| |
positive
|
110 (39)
|
139 (51)
| |
93 (45)
|
119 (44)
| |
|
T stage
|
T1–2
|
262 (93)
|
235 (86)
|
0.01
|
180 (88)
|
245 (90)
|
0.36
|
| |
T3–4
|
21 (7)
|
39 (14)
| |
25 (12)
|
26 (10)
| |
|
Grade
|
grade 1–2
|
279 (99)
|
90 (33)
|
< 0.001
|
142 (69)
|
171 (63)
|
0.16
|
| |
grade 3
|
4 (1)
|
184 (67)
| |
63 (31)
|
100 (37)
| |
|
PgR
|
negative
|
116 (42)
|
143 (52)
|
0.02
|
92 (46)
|
132 (50)
|
0.42
|
| |
positive
|
157 (58)
|
130 (48)
| |
108 (54)
|
133 (50)
| |
|
Her2
|
negative
|
257 (93)
|
226 (84)
|
< 0.001
|
180 (90)
|
233 (87)
|
0.46
|
| |
positive
|
3 (1)
|
38 (14)
| |
13 (7)
|
22 (8)
| |
| |
missing
|
16 (6)
|
6 (2)
| |
7 (4)
|
12 (4)
| |
|
Ki67
|
< 5%
|
104(53)
|
94 (42)
|
0.02
|
72 (54)
|
92 (46)
|
0.78
|
| |
≥ 5%
|
92 (47)
|
130 (58)
| |
88 (55)
|
106 (54)
| |
|
Cyclin D1
|
below median
|
106 (53)
|
100 (42)
|
0.02
|
76 (49)
|
105 (48)
|
0.85
|
| |
above median
|
93 (47)
|
140 (58)
| |
80 (51)
|
115 (52)
| |
|
mitotic count
|
< 8 per 2 mm2
|
283 (100)
|
0(0)
|
na
|
116 (57)
|
126 (47)
|
0.03
|
| |
≥ 8 per 2 mm2
|
0(0)
|
274 (100)
| |
87 (43)
|
142 (53)
| |
|
CCND1 log 2 copy number ratiob
|
< 0
|
116 (48)
|
87 (38)
|
0.03
|
205 (100)
|
0(0)
|
na
|
|
> 0
|
126 (52)
|
142 (62)
| |
0(0)
|
271 (100)
| |
- aChi-square test, analysis based on cases without missing values
- bprobe set 2
