Fig. 1

Expression status of CBS (a), CSE (b) and MPST (c) in renal tumors compared to non-affected kidney tissue from the same patient. From 26 renal tumors, 2 were determined as angiomyolipoma (AML; gray columns), 3 as papillary carcinoma (PC; white columns) and 21 as clear cell renal cell carcinoma (ccRCC; black columns). CBS was downregulated, or not changed in all tumors of renal cell clear cell carcinoma, while in angiomyolipoma and papillary carcinoma CBS was upregulated (a). CSE mRNA was downregulated in all types of tumors compared to corresponding healthy part of kidney (b). MPST mRNA was downregulated in almost all samples of clear cell renal cell carcinoma (c; except of one). Results are displayed as a fold of change to the expression of healthy tissue. In ccRCC, overall change in CBS (d), CSE (e) and MPST (f) from 21 patients revealed significant down-regulation, when compared to the healthy kidney tissue from the same patients. Since groups of angiomyolipoma and papillary carcinoma were negligible, we did not calculate statistical significance for these types of tumors. Results are displayed as mean ± S.E.M. and represent an average of 21patients. Statistical significance compared to corresponding controls represents * p < 0.05 and *** - p < 0.0001