Table 1 Clinicopathological characteristics of patients with hepatocellular carcinoma (HCC) according to forkhead box protein C2 (FOXC2) expression
Parameters | FOXC2 | P value | |
|---|---|---|---|
Low expressionn = 58 (%) | High expressionn = 26 (%) | ||
Age (years) | |||
  < 65 | 18 (31.0) | 6 (23.1) | 0.603 |
  ≥ 65 | 40 (69.0) | 20 (76.9) |  |
Gender | |||
 Male | 46 (79.3) | 19 (73.1) | 0.578 |
 Female | 12 (20.7) | 7 (26.9) |  |
Liver cirrhosis | |||
 Negative | 40 (69.0) | 11 (42.3) | 0.0296a |
 Positive | 18 (31.0) | 15 (57.7) |  |
T classification | |||
 1 | 5 (8.6) | 3 (11.6) | 0.333 |
 2 | 20 (34.5) | 5 (19.2) |  |
 3 | 28 (48.3) | 13 (50.0) |  |
 4 | 5 (8.6) | 5 (19.2) |  |
Differentiation | |||
 Well or Moderate | 57 (98.3) | 22 (84.7) | 0.0302a |
 Poor | 1 (1.7) | 4 (15.3) |  |
Tumor size (mm) | |||
  ≤ 20 | 5 (8.6) | 4 (18.2) | 0.449 |
  > 20 | 53 (91.4) | 22 (81.8) |  |
Pattern of tumor growth | |||
 Eg | 49 (84.5) | 18 (55.6) | 0.143 |
 Ig | 9 (15.5) | 8 (44.4) |  |
Fc-Inf | |||
 Negative | 37 (63.8) | 11 (42.3) | 0.0948 |
 Positive | 21 (36.2) | 15 (57.7) |  |
IM | |||
 Negative | 50 (86.2) | 20 (76.9) | 0.347 |
 Positive | 8 (13.8) | 6 (23.1) |  |
Vv | |||
 Negative | 46 (79.3) | 22 (81.8) | 0.766 |
 Positive | 12 (20.7) | 4 (18.2) |  |
Vp | |||
 Negative | 38 (65.5) | 17 (65.4) | 1 |
 Positive | 20 (34.5) | 9 (34.6) |  |
Va | |||
 Negative | 55 (94.8) | 25 (96.2) | 1 |
 Positive | 3 (5.2) | 1 (3.8) |  |
AFP level (ng/ml) (n = 73) | |||
 Normal (≤10) | 27 (55.1) | 3 (12.5) | 0.000777a |
 High (> 10) | 22 (44.9) | 21 (87.5) |  |
PIVKA II level (AU/ml) (n = 69) | |||
 Normal (≤40) | 19 (39.6) | 11 (52.4) | 0.43 |
 High (> 40) | 29 (60.4) | 10 (47.6) |  |
Ki67 labeling index | |||
  < 1% | 21 (36.2) | 3 (11.5) | 0.0348a |
  ≥ 1% | 37 (63.8) | 23 (88.5) |  |