Increased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma

Table 2 Age, gender and general biochemical parameters in control subjects and HCC patients

Parameters	Controls (n = 30)	HCC patients (n = 30)	Mann-Whitney Test
Parameters	Controls (n = 30)	HCC patients (n = 30)	p value
Age (years)
Mean ± SD	53.47 ± 6.64	54.37 ± 11.33
Median (IQR)	55.0 (48.75-58.00)	56.50 (50.75-62.00)	0.213
Gender (Male/Female)	20/10	20/10
Total bilirubin (mg/dl)
Mean ± SD	0.71 ± 0.09	2.50 ± 0.4.65
Median (IQR)	0.70 (0.68-0.73)	1.20 (0.78-1.73)	< 0.0001
Direct bilirubin (mg/dl)
Mean ± SD	0.23 ± 0.05	0.77 ± 1.19
Median (IQR)	0.20 (0.20-0.30)	0.40 (0.20-0.80)	< 0.0001
Total protein (gm/dl)
Mean ± SD	7.33 ± 0.36	6.79 ± 0.94	< 0.01
Median (IQR)	7.30 (7.20-7.60)	6.85 (6.18-7.55)
Albumin (gm/dl)
Mean ± SD	3.97 ± 0.32	3.14 ± 0.67
Median (IQR)	4.10 (3.60-4.30)	3.05 (2.68-3.60)	< 0.0001
AST (IU/L)
Mean ± SD	22.90 ± 6.61	118.2 ± 99.87
Median (IQR)	21.00 (19.75-28.00)	78.00 (51.00-148.5)	< 0.0001
ALT (IU/L)
Mean ± SD	24.90 ± 8.40	60.79 ± 38.13
Median (IQR)	23.00 (19.00-32.25)	45.00 (35.00-79.50)	< 0.0001
γGT (IU/L)
Mean ± SD	27.47 ± 10.46	142.5 ± 136.0
Median (IQR)	27.00 (19.50-32.00)	92.50 (57.00-159.0)	< 0.0001
ALP (IU/L)
Mean ± SD	176.2 ± 30.55	663.0 ± 654.2
Median (IQR)	180.0 (155.8-196.3)	480.5 (282.8-680.0)	< 0.0001

ALT alanine transaminase, AST aspartate transaminase, γGT gamma glutamyl transpeptidase, ALP alkaline phosphatase

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