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Table 3 Correlation analysis between non-synonymous mutations of all targeted genes of CAGE and baseline characteristics in the 46 patients with oral squamous cell carcinoma

From: Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma

Characteristics Total patients N = 46 Non-synonymous mutations P value*
+
n (%) n (%) n (%)
Gender
 Male 12 (26.1) 10 (25.0) 2 (33.3) 0.644
 Female 34 (73.9) 30 (75.0) 4 (66.7)
Age (years)
  < 60 27 (58.7) 23 (57.5) 4 (66.7) 1.000
  ≥ 60 19 (41.3) 17 (42.5) 2 (33.3)
Site
 Tongue 19(41.3) 18(45.0) 1(16.7) 0.182
 Buccal 6(13.0) 6(15.0) 0(0.0)
 Gingiva 6(13.0) 5(12.5) 1(16.7)
 Floor of mouth 3(6.5) 2(5.0) 1(16.7)
 Palate 9(19.6) 6 (15.0) 3 (50.0)
 Retromolar trigone 3(6.5) 3(7.5) 0(0.0)
Clinical T stage
 T1/T2 13(28.3) 11(27.5) 2(33.3) 1.000
 T3/T4 33 (71.7) 29(72.5) 4(66.7)
Clinical N stage
 N0 14(30.4) 11(27.5) 3 (50.0) 0.633
 N1 12(26.1) 11(27.5) 1(16.7)
 N2 20(43.5) 18(45.0) 2(33.3)
Clinical stage
 III 22(47.8) 19(47.5) 3 (50.0) 1.000
 IVA 24(52.2) 21(52.5) 3 (50.0)
Pathological differentiation grade
 Well 13(28.3) 11(27.5) 2(33.3) 1.000
 Moderately/Poorly 33(71.7) 29(72.5) 4(66.7)
Smoking statusa
 Current/former 19(41.3) 17(42.5) 2(33.3) 1.000
 Never 27(58.7) 23 (57.5) 4(66.7)
Alcohol useb
 Positive 24(52.2) 22(55.0) 2(33.3) 0.405
 Negative 22(47.8) 18(45.0) 4(66.7)
  1. *P value from the chi-square test was reported to compare the difference between the patients with and without non-synonymous mutation of targeted genes based on different baseline characteristics
  2. aFormer/current smokers defined as at least a one pack-year history of smoking
  3. bPositive alcohol use was defined as current alcohol use of more than one drink per day for 1 year (12 oz of beer with 5% alcohol, or 5 oz of wine with 12–15% alcohol, or one ounce of liquor with 45–60% alcohol). All other patients were classified as negative alcohol use
  4. Note: No significant correlation was found between the non-synonymous mutant status of all targeted genes of CAGE and baseline characteristics in the 46 patients with oral squamous cell carcinoma