Table 4 Drug-related adverse events n = 54
Adverse events | |||||
|---|---|---|---|---|---|
Grade 1 (%) | Grade 2 (%) | Grade 3 (%) | Grade 4 (%) | All grades (%) | |
Leukopenia | 16 (29.6) | 22 (40.7) | 3 (5.6) | 0 | 41 (75.9) |
Neutropenia | 11 (20.4) | 14 (25.9) | 13 (24.1) | 1 (1.9) | 39 (72.2) |
Anemia | 17 (31.5) | 8 (14.8) | 0 | 0 | 25 (46.3) |
Thrombocytopenia | 13 (24.1) | 11 (20.4) | 7 (13.0) | 2 (3.7) | 33 (61.1) |
Febrile neutropenia | – | – | 1 (1.9) | 0 | 1 (1.9) |
Skin hyperpigmentation | 25 (46.3) | 0 | – | – | 25 (46.3) |
Malaise | 29 (53.7) | 0 | – | – | 29 (53.7) |
Nausea | 25 (46.3) | 13 (24.1) | 4 (7.4) | – | 42 (77.8) |
Vomiting | 7 (13.0) | 7 (13.0) | 7 (13.0) | 0 | 21 (38.9) |
Laryngeal mucositis | 2 (3.7) | 0 | 0 | 0 | 2 (3.7) |
Diarrhea | 2 (3.7) | 1 (1.9) | 1 (1.9) | 0 | 4 (7.4) |
Peripheral sensory neuropathy | 32 (59.3) | 1 (1.9) | 0 | 0 | 33 (61.1) |
Palmer-planter erythrodysestheia syndrome | 1 (1.9) | 0 | 0 | – | 1 (1.9) |
Alanine aminotransferase increased | 9 (16.7) | 3 (5.6) | 0 | 0 | 12 (22.2) |