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Table 4 Drug-related adverse events n = 54

From: Phase II study of adjuvant chemotherapy with S1 plus oxaliplatin for Chinese patients with gastric cancer

Adverse events
  Grade 1 (%) Grade 2 (%) Grade 3 (%) Grade 4 (%) All grades (%)
Leukopenia 16 (29.6) 22 (40.7) 3 (5.6) 0 41 (75.9)
Neutropenia 11 (20.4) 14 (25.9) 13 (24.1) 1 (1.9) 39 (72.2)
Anemia 17 (31.5) 8 (14.8) 0 0 25 (46.3)
Thrombocytopenia 13 (24.1) 11 (20.4) 7 (13.0) 2 (3.7) 33 (61.1)
Febrile neutropenia 1 (1.9) 0 1 (1.9)
Skin hyperpigmentation 25 (46.3) 0 25 (46.3)
Malaise 29 (53.7) 0 29 (53.7)
Nausea 25 (46.3) 13 (24.1) 4 (7.4) 42 (77.8)
Vomiting 7 (13.0) 7 (13.0) 7 (13.0) 0 21 (38.9)
Laryngeal mucositis 2 (3.7) 0 0 0 2 (3.7)
Diarrhea 2 (3.7) 1 (1.9) 1 (1.9) 0 4 (7.4)
Peripheral sensory neuropathy 32 (59.3) 1 (1.9) 0 0 33 (61.1)
Palmer-planter erythrodysestheia syndrome 1 (1.9) 0 0 1 (1.9)
Alanine aminotransferase increased 9 (16.7) 3 (5.6) 0 0 12 (22.2)