Fig. 4

Proposed mechanisms of ABCG2 Q141K SNP and patient outcome. NSCLC patient who is treated with gemcitabine and have ABCG2 Q141K either heterozygous or homozygous allele could increase their survival because of accumulating more gemcitabine inside cancer cells and is thus more effective in killing cancer cells. However, probability of increasing toxicity can occur since other substrates of ABCG2 can be accumulated inside normal/healthy cells and thus cause cell death. These healthy cells can include cells in the bone marrow that produce blood e.g. platelets