Fig. 3
![Fig. 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12885-018-4464-9/MediaObjects/12885_2018_4464_Fig3_HTML.gif)
SETDB1 promoted cell metastasis both in vivo and vitro in HCC. a and b Transwell and Boyden assays indicate SETDB1 could enhance cell migration and invasion. The invasive cells were stained and counted under microscope at 24–30 h after reseeding. Original magnification, × 400. ** P<0.01, as compared LV-SET with WT and LV-con groups, or LV-SET with WT and LV-shcon groups. c SETDB1 significantly promoted HCC tumorigenicity in vivo as demonstrated by an orthotopic tumor implantation experiment in nude mice. d SETDB1 increased lung metastasis in an orthotopic tumor implantation model in nude mice. Hematoxylin and eosin staining confirming the formation of HCC tumor foci in the lungs. e SETDB1 modulates EMT-related genes expression