Fig. 1
From: Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells
Growth inhibition assay with single agent or combination of sorafenib and selumetinib. a Cell lines were treated with different concentrations of selumetinib for ten days (mean values +/− SEM). b Cell lines were treated with different concentrations of sorafenib for ten days (mean values +/− SEM). c Combination indices (CI) were calculated by CompuSyn Software from the data of viability assays of selumetinib and sorafenib combination treatment (Additional file 1: Figure S1). CI values less than 1 indicate synergy while values equal to or more than 1 represent additive or antagonistic effect, respectively