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Table 1 Known resistance mutations in the SMO domain. Source: COSMIC http://cancer.sanger.ac.uk/cosmic[16]

From: A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy

Mutation

Number

Associated with

 

of samples

BCC initiation

H231R

2

Yes

T241M

1

No

W281C

2

Yes

W281L

1

No

V321A

1

Yes

V321M

3

Yes

A459V

3

Yes

F460L

1

Yes

C469Y

1

No

D473G

7

Yes

D473H

2

Yes

D473N

1

Yes

D473Y

1

No

Q477E

1

Yes

G497W

3

Yes

S533N

1

Yes

W535L

10

Yes

W535R

1

Yes

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BMC Cancer

ISSN: 1471-2407

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