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Table 5 Correlation of α-internexin methylation status with protein expression (major results)

From: Loss of expression and prognosis value of alpha-internexin in gastroenteropancreatic neuroendocrine neoplasm

 

Methylation levels, % Median (range)

Z value

P value

α-internexin (−)

α-internexin (+)

GEP-NENs (n = 116)

 Average of total 12 CpG sites

65.8 (0–85.3)

64.1 (0–79.5)

1.692

0.091

 S4

63.3 (0–80.8)

57.8 (0–73.5)

2.424

0.015

 S6

66.0 (0–89.3)

61.0 (0–81.4)

2.338

0.019

GI-NENs (n = 54)

 Average of total 12 CpG sites

68.5 (0–81.7)

61.8 (11.5–67.8)

2.539

0.011

 S1

53.2 (0–100)

45.8 (12.6–61.8)

2.062

0.039

 S2

53.5 (0–68.3)

41.6 (0–55.3)

2.855

0.004

 S3

50.0 (0–67.3)

41.3 (0–52.6)

2.633

0.008

 S4

64.6 (0–79.5)

56.7 (0–65.6)

2.897

0.004

 S5

65.6 (0–85.7)

62.1 (11.5–76.3)

2.094

0.036

 S6

67.4 (0–89.3)

56.0 (0–68.0)

3.130

0.002

 S7

66.0 (0–85.7)

61.0 (0–69.4)

2.105

0.035

 S8

82.9 (0–93.8)

70.3 (0–84.1)

2.583

0.010

 S9

66.2 (0–84.4)

54.9 (0–67.7)

2.695

0.007

 S10

80.5 (0–93.6)

65.4 (0–81.6)

2.606

0.009

 S11

83.2 (0–96.9)

76.0 (10.8–83.3)

2.517

0.012

 S12

78.6 (0–88.2)

66.6 (13.2–79.0)

2.595

0.009

pNENs (n = 49)

 Average of total 12 CpG sites

63.6 (49.1–85.3)

66.0 (24.0–79.5)

0.164

0.870

  1. S1, S2...S12 means each CpG site in the region (+ 729~ + 834) of α-internexin
  2. GEP-NEN Gastroenteropancreatic neuroendocrine neoplasm, GI-NEN Gastrointestinal neuroendocrine neoplasm; pNEN: Pancreatic neuroendocrine neoplasm