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Table 1 Blood counts in control mice and mice at 2, 4, 5 and 6 weeks after cancer cells inoculation

From: Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation

  Control 2nd week 4th week 5th week 6th week
PLT [K. μl− 1] 916.30 ± 47.39 618.75 ± 128.13# 892.81 ± 30.04 1067.25 ± 87.86 964.58 ± 119.81
MPV [fl] 5.21 ± 0.06 5.63 ± 0.13* 5.44 ± 0.06 5.73 ± 0.42 5.82 ± 0.12**
RBC [M. μl−1] 10.37 ± 0.17 10.50 ± 0.15 10.16 ± 0.22 10.27 ± 0.23 10.72 ± 0.30
MCH [pg] 15.69 ± 0.20 14.67 ± 0.06* 15.28 ± 0.15 15.60 ± 0.27 15.74 ± 0.21
HCT [%] 57.40 ± 0.96 57.92 ± 0.93 56.78 ± 1.12$ 57.63 ± 1.15 62.84 ± 2.01
MCV [fl] 55.33 ± 0.18 55.15 ± 0.31 55.92 ± 0.32 55.10 ± 0.32 58.75 ± 0.70*
WBC [K. μl−1] 3.87 ± 0.21 2.94 ± 0.26 31.80 ± 6.14 169.35 ± 49.59** 351.50 ± 79.54****
LYM [K. μl−1] 2.88 ± 0.15 2.65 ± 0.60 9.96 ± 1.26 33.62 ± 8.15** 62.19 ± 11.43****
MON [K. μl−1] 0.15 ± 0.02 0.15 ± 0.02 3.59 ± 0.76 18.46 ± 5.67** 40.53 ± 8.15****
GRA [K. μl−1] 0.84 ± 0.08 0.62 ± 0.09 18.46 ± 4.54 117.27 ± 36.28* 224.36 ± 69.17****
LYM [%] 76.14 ± 1.39 75.35 ± 2.00 40.83 ± 5.03**** 32.19 ± 4.69**** 20.09 ± 1.86****
MON [%] 5.25 ± 0.26 6.69 ± 0.45 10.27 ± 0.83**** 10.34 ± 0.64**** 11.74 ± 0.98****
GRA [%] 18.61 ± 1.39 17.97 ± 1.71 48.91 ± 4.70* 57.47 ± 4.43*** 68.17 ± 2.48****
  1. Data are expressed as mean ± SEM
  2. PLT platelets, MPV mean platelet volume, RBC red blood cells, MCH mean cell haemoglobin, HCT haematocrit, MCV mean corpuscular volume, WBC white blood cells, LYM lymphocytes, MON monocytes, GRA granulocytes
  3. *p < 0.05, **p < 0.01, ***p < 0.001, and **** P < 0.0001 vs. control group; #p < 0.05 vs. 5-week group; $p < 0.05 vs. 6-week group, (n = 8–12)