Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation

Table 1 Blood counts in control mice and mice at 2, 4, 5 and 6 weeks after cancer cells inoculation

	Control	2nd week	4th week	5th week	6th week
PLT [K. μl^− 1]	916.30 ± 47.39	618.75 ± 128.13#	892.81 ± 30.04	1067.25 ± 87.86	964.58 ± 119.81
MPV [fl]	5.21 ± 0.06	5.63 ± 0.13*	5.44 ± 0.06	5.73 ± 0.42	5.82 ± 0.12**
RBC [M. μl⁻¹]	10.37 ± 0.17	10.50 ± 0.15	10.16 ± 0.22	10.27 ± 0.23	10.72 ± 0.30
MCH [pg]	15.69 ± 0.20	14.67 ± 0.06*	15.28 ± 0.15	15.60 ± 0.27	15.74 ± 0.21
HCT [%]	57.40 ± 0.96	57.92 ± 0.93	56.78 ± 1.12$	57.63 ± 1.15	62.84 ± 2.01
MCV [fl]	55.33 ± 0.18	55.15 ± 0.31	55.92 ± 0.32	55.10 ± 0.32	58.75 ± 0.70*
WBC [K. μl⁻¹]	3.87 ± 0.21	2.94 ± 0.26	31.80 ± 6.14	169.35 ± 49.59**	351.50 ± 79.54****
LYM [K. μl⁻¹]	2.88 ± 0.15	2.65 ± 0.60	9.96 ± 1.26	33.62 ± 8.15**	62.19 ± 11.43****
MON [K. μl⁻¹]	0.15 ± 0.02	0.15 ± 0.02	3.59 ± 0.76	18.46 ± 5.67**	40.53 ± 8.15****
GRA [K. μl⁻¹]	0.84 ± 0.08	0.62 ± 0.09	18.46 ± 4.54	117.27 ± 36.28*	224.36 ± 69.17****
LYM [%]	76.14 ± 1.39	75.35 ± 2.00	40.83 ± 5.03****	32.19 ± 4.69****	20.09 ± 1.86****
MON [%]	5.25 ± 0.26	6.69 ± 0.45	10.27 ± 0.83****	10.34 ± 0.64****	11.74 ± 0.98****
GRA [%]	18.61 ± 1.39	17.97 ± 1.71	48.91 ± 4.70*	57.47 ± 4.43***	68.17 ± 2.48****

Data are expressed as mean ± SEM
PLT platelets, MPV mean platelet volume, RBC red blood cells, MCH mean cell haemoglobin, HCT haematocrit, MCV mean corpuscular volume, WBC white blood cells, LYM lymphocytes, MON monocytes, GRA granulocytes
*p < 0.05, **p < 0.01, ***p < 0.001, and **** P < 0.0001 vs. control group; #p < 0.05 vs. 5-week group; $p < 0.05 vs. 6-week group, (n = 8–12)

ISSN: 1471-2407