Fig. 5
![Fig. 5](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12885-018-4440-4/MediaObjects/12885_2018_4440_Fig5_HTML.gif)
Next-generation sequencing based characterization of NCH644 and NCH421k CIN knockdown cells. a After CIN knockdown there are 409 upregulated and 258 downregulated genes in NCH644 CIN shRNA cells as compared to CTRL cells. b After CIN knockdown there are 172 upregulated and 66 downregulated genes in NCH421k CIN shRNA cells as compared to CTRL cells. c Heatmap of the Top100 differentially regulated genes (sorted by adjusted p-value, based on rlog normalized counts) in NCH644. Hierarchical clustering separates control cells and knockdown cells efficiently. d Heatmap of the Top100 differentially regulated genes (sorted by adjusted p-value, based on rlog normalized counts) in NCH421k. Hierarchical clustering separates control cells and knockdown cells efficiently