Table 4 Differences by key breast cancer variables among metabolites that showed a greater than 20% case-control difference

ER + (n = 23)

ER - (n = 10)

P-value¹

PR + (n = 24)

PR - (n = 9)

P-value^a

1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1) ^b

Plasmalogen

1.16 (0.26)

1.26 (0.35)

0.14

1.15 (0.27)

1.29 (0.32)

0.75

1-linoleoyl-GPA (18:2) ^b

Lysolipid

1.50 (1.03)

1.21 (0.62)

0.25

1.54 (0.99)

1.08 (0.63)

0.3

1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2) ^b

Phospholipid

1.19 (0.60)

1.26 (0.40)

0.52

1.22 (0.60)

1.21 (0.41)

0.59

1-palmitoyl-GPG (16:0) ²

Lysolipid

1.08 (0.89)

0.76 (0.41)

0.11

1.06 (0.88)

0.80 (0.40)

0.1

1-palmitoylglycerol (16:0)

Monoacylglycerol

1.19 (0.45)

1.07 (0.35)

0.62

1.17 (0.47)

1.13 (0.29)

0.11

2-ethylphenylsulfate

Benzoate

0.63 (0.63)

0.59 (0.52)

0.53

0.65 (0.62)

0.55 (0.53)

0.51

3-(cystein-S-yl)acetaminophen²

Xanthine

0.92 (2.06)

0.36 (0.34)

0.07

0.89 (2.02)

0.38 (0.35)

0.1

4-acetylphenol sulfate

Drug

1.23 (1.96)

1.31 (1.00)

0.39

1.98 (4.78)

0.98 (0.40)

0.29

adrenate (22:4n6)

Polyunsaturated fatty acid (n3 and n6)

1.03 (0.65)

0.80 (0.48)

0.21

1.07 (0.66)

0.69 (0.32)

0.04

asparagine

Alanine and aspartate

1.11 (0.24)

1.19 (0.43)

0.1

1.12 (0.24)

1.19 (0.46)

0.02

cysteine s-sulfate

Glycogen

6.17 (8.69)

4.92 (7.29)

0.44

6.34 (8.80)

4.33 (6.56)

0.25

cysteinylglycine

Glutathione

1.23 (0.67)

1.28 (0.62)

0.56

1.27 (0.65)

1.19 (0.69)

0.9

ergothioneine

Food component/plant

1.55 (1.41)

1.27 (0.85)

0.45

1.57 (1.39)

1.18 (0.82)

0.36

glycerate

Glycolysis, Gluconeogenesis, and Pyruvate

1.23 (0.40)

1.26 (0.61)

0.2

1.23 (0.40)

1.24 (0.63)

0.25

glycolithocholate

Secondary bile acid

2.01 (4.89)

1.01 (0.42)

0.24

1.31 (1.92)

1.13 (1.03)

0.44

heptanoate (7:0)

Medium chain fatty acid

0.88 (1.22)

0.75 (0.51)

0.41

0.65 (0.68)

1.33 (1.64)

0.08

indoleacetate

Tryptophan

1.02 (0.53)

1.24 (0.92)

0.64

1.11 (0.74)

1.03 (0.41)

0.03

indoleacetylglutamine

Tryptophan

0.46 (0.06)

0.54 (0.31)

0.01

0.50 (0.21)

0.44 (0)

0.12

laurylcarnitine

Fatty acid (acyl carnitine)

1.15 (0.86)

0.82 (0.45)

0.04

0.20 (0.82)

0.69 (0.46)

0.05

maltotriose

Glycogen

0.94 (0.49)

0.97 (0.44)

0.8

0.88 (0.42)

1.13 (0.55)

0.44

N-(2-furoyl)glycine

Food component/plant

3.46 (5.33)

5.71 (6.53)

0.72

2.87 (4.18)

7.55 (7.90)

0.04

sphingosine

Sphingolipid

0.83 (0.52)

0.83 (0.68)

0.11

0.84 (0.55)

0.80 (0.63)

0.69

sphingosine 1-phosphate

Sphingolipid

0.94 (0.46)

0.94 (0.39)

0.37

0.92 (0.46)

0.99 (0.39)

0.42

threonine

Glycine, serine, and threonine

1.08 (0.22)

1.10 (0.30)

0.31

1.09 (0.26)

1.08 (0.19)

0.46