Metabolite | Metabolism Pathway | ER Status mean levels (standard deviation) | PR Status mean levels (standard deviation) | ||||
---|---|---|---|---|---|---|---|
ER + (n = 23) | ER - (n = 10) | P-value1 | PR + (n = 24) | PR - (n = 9) | P-valuea | ||
1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1) b | Plasmalogen | 1.16 (0.26) | 1.26 (0.35) | 0.14 | 1.15 (0.27) | 1.29 (0.32) | 0.75 |
1-linoleoyl-GPA (18:2) b | Lysolipid | 1.50 (1.03) | 1.21 (0.62) | 0.25 | 1.54 (0.99) | 1.08 (0.63) | 0.3 |
1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2) b | Phospholipid | 1.19 (0.60) | 1.26 (0.40) | 0.52 | 1.22 (0.60) | 1.21 (0.41) | 0.59 |
1-palmitoyl-GPG (16:0) 2 | Lysolipid | 1.08 (0.89) | 0.76 (0.41) | 0.11 | 1.06 (0.88) | 0.80 (0.40) | 0.1 |
1-palmitoylglycerol (16:0) | Monoacylglycerol | 1.19 (0.45) | 1.07 (0.35) | 0.62 | 1.17 (0.47) | 1.13 (0.29) | 0.11 |
2-ethylphenylsulfate | Benzoate | 0.63 (0.63) | 0.59 (0.52) | 0.53 | 0.65 (0.62) | 0.55 (0.53) | 0.51 |
3-(cystein-S-yl)acetaminophen2 | Xanthine | 0.92 (2.06) | 0.36 (0.34) | 0.07 | 0.89 (2.02) | 0.38 (0.35) | 0.1 |
4-acetylphenol sulfate | Drug | 1.23 (1.96) | 1.31 (1.00) | 0.39 | 1.98 (4.78) | 0.98 (0.40) | 0.29 |
adrenate (22:4n6) | Polyunsaturated fatty acid (n3 and n6) | 1.03 (0.65) | 0.80 (0.48) | 0.21 | 1.07 (0.66) | 0.69 (0.32) | 0.04 |
asparagine | Alanine and aspartate | 1.11 (0.24) | 1.19 (0.43) | 0.1 | 1.12 (0.24) | 1.19 (0.46) | 0.02 |
cysteine s-sulfate | Glycogen | 6.17 (8.69) | 4.92 (7.29) | 0.44 | 6.34 (8.80) | 4.33 (6.56) | 0.25 |
cysteinylglycine | Glutathione | 1.23 (0.67) | 1.28 (0.62) | 0.56 | 1.27 (0.65) | 1.19 (0.69) | 0.9 |
ergothioneine | Food component/plant | 1.55 (1.41) | 1.27 (0.85) | 0.45 | 1.57 (1.39) | 1.18 (0.82) | 0.36 |
glycerate | Glycolysis, Gluconeogenesis, and Pyruvate | 1.23 (0.40) | 1.26 (0.61) | 0.2 | 1.23 (0.40) | 1.24 (0.63) | 0.25 |
glycolithocholate | Secondary bile acid | 2.01 (4.89) | 1.01 (0.42) | 0.24 | 1.31 (1.92) | 1.13 (1.03) | 0.44 |
heptanoate (7:0) | Medium chain fatty acid | 0.88 (1.22) | 0.75 (0.51) | 0.41 | 0.65 (0.68) | 1.33 (1.64) | 0.08 |
indoleacetate | Tryptophan | 1.02 (0.53) | 1.24 (0.92) | 0.64 | 1.11 (0.74) | 1.03 (0.41) | 0.03 |
indoleacetylglutamine | Tryptophan | 0.46 (0.06) | 0.54 (0.31) | 0.01 | 0.50 (0.21) | 0.44 (0) | 0.12 |
laurylcarnitine | Fatty acid (acyl carnitine) | 1.15 (0.86) | 0.82 (0.45) | 0.04 | 0.20 (0.82) | 0.69 (0.46) | 0.05 |
maltotriose | Glycogen | 0.94 (0.49) | 0.97 (0.44) | 0.8 | 0.88 (0.42) | 1.13 (0.55) | 0.44 |
N-(2-furoyl)glycine | Food component/plant | 3.46 (5.33) | 5.71 (6.53) | 0.72 | 2.87 (4.18) | 7.55 (7.90) | 0.04 |
sphingosine | Sphingolipid | 0.83 (0.52) | 0.83 (0.68) | 0.11 | 0.84 (0.55) | 0.80 (0.63) | 0.69 |
sphingosine 1-phosphate | Sphingolipid | 0.94 (0.46) | 0.94 (0.39) | 0.37 | 0.92 (0.46) | 0.99 (0.39) | 0.42 |
threonine | Glycine, serine, and threonine | 1.08 (0.22) | 1.10 (0.30) | 0.31 | 1.09 (0.26) | 1.08 (0.19) | 0.46 |