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Table 4 Differences by key breast cancer variables among metabolites that showed a greater than 20% case-control difference

From: Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry

Metabolite Metabolism Pathway ER Status mean levels (standard deviation) PR Status mean levels (standard deviation)
   ER + (n = 23) ER - (n = 10) P-value1 PR + (n = 24) PR - (n = 9) P-valuea
1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1) b Plasmalogen 1.16 (0.26) 1.26 (0.35) 0.14 1.15 (0.27) 1.29 (0.32) 0.75
1-linoleoyl-GPA (18:2) b Lysolipid 1.50 (1.03) 1.21 (0.62) 0.25 1.54 (0.99) 1.08 (0.63) 0.3
1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2) b Phospholipid 1.19 (0.60) 1.26 (0.40) 0.52 1.22 (0.60) 1.21 (0.41) 0.59
1-palmitoyl-GPG (16:0) 2 Lysolipid 1.08 (0.89) 0.76 (0.41) 0.11 1.06 (0.88) 0.80 (0.40) 0.1
1-palmitoylglycerol (16:0) Monoacylglycerol 1.19 (0.45) 1.07 (0.35) 0.62 1.17 (0.47) 1.13 (0.29) 0.11
2-ethylphenylsulfate Benzoate 0.63 (0.63) 0.59 (0.52) 0.53 0.65 (0.62) 0.55 (0.53) 0.51
3-(cystein-S-yl)acetaminophen2 Xanthine 0.92 (2.06) 0.36 (0.34) 0.07 0.89 (2.02) 0.38 (0.35) 0.1
4-acetylphenol sulfate Drug 1.23 (1.96) 1.31 (1.00) 0.39 1.98 (4.78) 0.98 (0.40) 0.29
adrenate (22:4n6) Polyunsaturated fatty acid (n3 and n6) 1.03 (0.65) 0.80 (0.48) 0.21 1.07 (0.66) 0.69 (0.32) 0.04
asparagine Alanine and aspartate 1.11 (0.24) 1.19 (0.43) 0.1 1.12 (0.24) 1.19 (0.46) 0.02
cysteine s-sulfate Glycogen 6.17 (8.69) 4.92 (7.29) 0.44 6.34 (8.80) 4.33 (6.56) 0.25
cysteinylglycine Glutathione 1.23 (0.67) 1.28 (0.62) 0.56 1.27 (0.65) 1.19 (0.69) 0.9
ergothioneine Food component/plant 1.55 (1.41) 1.27 (0.85) 0.45 1.57 (1.39) 1.18 (0.82) 0.36
glycerate Glycolysis, Gluconeogenesis, and Pyruvate 1.23 (0.40) 1.26 (0.61) 0.2 1.23 (0.40) 1.24 (0.63) 0.25
glycolithocholate Secondary bile acid 2.01 (4.89) 1.01 (0.42) 0.24 1.31 (1.92) 1.13 (1.03) 0.44
heptanoate (7:0) Medium chain fatty acid 0.88 (1.22) 0.75 (0.51) 0.41 0.65 (0.68) 1.33 (1.64) 0.08
indoleacetate Tryptophan 1.02 (0.53) 1.24 (0.92) 0.64 1.11 (0.74) 1.03 (0.41) 0.03
indoleacetylglutamine Tryptophan 0.46 (0.06) 0.54 (0.31) 0.01 0.50 (0.21) 0.44 (0) 0.12
laurylcarnitine Fatty acid (acyl carnitine) 1.15 (0.86) 0.82 (0.45) 0.04 0.20 (0.82) 0.69 (0.46) 0.05
maltotriose Glycogen 0.94 (0.49) 0.97 (0.44) 0.8 0.88 (0.42) 1.13 (0.55) 0.44
N-(2-furoyl)glycine Food component/plant 3.46 (5.33) 5.71 (6.53) 0.72 2.87 (4.18) 7.55 (7.90) 0.04
sphingosine Sphingolipid 0.83 (0.52) 0.83 (0.68) 0.11 0.84 (0.55) 0.80 (0.63) 0.69
sphingosine 1-phosphate Sphingolipid 0.94 (0.46) 0.94 (0.39) 0.37 0.92 (0.46) 0.99 (0.39) 0.42
threonine Glycine, serine, and threonine 1.08 (0.22) 1.10 (0.30) 0.31 1.09 (0.26) 1.08 (0.19) 0.46
  1. aNot adjusted for multiple comparisons
  2. bIndicates compounds that have not been officially confirmed based on a standard, although identity is certain
  3. Significant data are in bold