Table 3 Factors associated with survival outcomes in patients with endometrioid histologic type of uterine corpus endometrial carcinoma
Characteristics | Overall survival | Progression-free survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
HR | 95% CI | P | Adjusted HR | 95% CI | P | HR | 95% CI | P | Adjusted HR | 95% CI | P | |
Age, years | ||||||||||||
≥ 63 | 1.712 | 0.773–3.790 | 0.185 | 2.044 | 0.887–4.710 | 0.093 | 1.617 | 0.859–3.045 | 0.137 | 1.853 | 0.955–3.595 | 0.068 |
< 63 | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − |
Grade | ||||||||||||
G3 | 3.041 | 1.379–6.704 | 0.006 | 1.817 | 0.768–4.302 | 0.174 | 1.322 | 0.702–2.489 | 0.388 | 0.889 | 0.452–1.746 | 0.733 |
G1,2 | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − |
FIGO stage | ||||||||||||
III-IV | 4.780 | 2.175–10.506 | < 0.001 | 4.400 | 1.870–10.354 | 0.001 | 3.402 | 1.762–6.567 | < 0.001 | 4.049 | 2.013–8.146 | < 0.001 |
I-II | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − |
LYL1 status | ||||||||||||
Amplification | 2.650 | 0.355–19.775 | 0.342 | 2.823 | 0.354–22.531 | 0.327 | 3.443 | 0.826–14.347 | 0.089 | 4.093 | 0.926–18.102 | 0.063 |
Non-amplification | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − | 1 (Ref) | − | − |