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Fig. 2 | BMC Cancer

Fig. 2

From: Laterally spreading tumour of the distal stomach: a case report

Fig. 2

Histopathological examination of the early biopsy revealed high-grade intraepithelial neoplasia of the gastric antrum near the greater curvature and tubulovillous adenomatoid hyperplasia with low-grade intraepithelial neoplasia in the antrum and pyloric region. The histopathologic assessment showed tubulovillous hyperplasia with moderate atypical hyperplasia of the glands with crowded cells in the antropyloric region at 100× (a). High magnification 400× showed disruption of polarity, extremely disordered glandular structures, deep staining that, infiltrated the stroma, crowded cells, and hyperchromatic nuclei (b). Histopathology of the ESD showed a disordered glandular structure and polarity, visible branching growth; damaged muscular mucosal layer, and expanded submucosal blood vessels at 40× (c). The nuclei are deeply stained and crowded at 400× (d). The surgical specimen is representative of showing highly to -moderately differentiated adenocarcinoma of the gastric antrum involving the muscularis mucosa, and of a tubulovillous adenoma of the pylorus. The glands are irregular with villous growth, visible branching and structural changes (e). The interstitial connective tissue is visible, and inflammatory cells are leaching (f). Immunostains showed that a portion of the glands are CEA positive (g), and CDX-2 positive (h)

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