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Fig. 1 | BMC Cancer

Fig. 1

From: Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

Fig. 1

Isolation and treatment of Type A and Type B exosomes (a). T-DM1 binds to Type A exosomes prepared from the cell culture medium of HER2-positive breast and gastric cancer cells. Immuno-electron microscopy images showing MCF-7 exosomes treated with T-DM1 (b), SKBR-3 exosomes treated with PBS (c), SKBR-3 exosomes treated with T-DM1 (d), and SNU-216 exosomes treated with T-DM1 (e). T-DM1 is present on exosomes derived from the HER2-positive cell lines (SKBR-3, SNU-216) and treated with T-DM1 (d, e), but not in the controls (b, c). Large arrows point at exosomes, small arrows at immuno-gold labelled T-DM1

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BMC Cancer

ISSN: 1471-2407

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