Table 2 Correlation of SOX9 expression with clinico-pathological parameters at time of surgery (according to TNM Classification of Malignant Tumours 8th edition 2017). Percent-values are given in parentheses
SOX9 | ||||
|---|---|---|---|---|
Characteristic | Total (%) | high positive | negative | p |
All patients | 211 (100) | 175 (82.9) | 36 (17.1) | |
Age (median. 66.5) years | ||||
≤ 66 | 104 (49.3) | 81 (38.4) | 23 (10.9) | 0.054 |
≥ 67 | 107 (50.7) | 94 (44.5) | 13 (6.2) | |
Gender | ||||
Male | 135 (64.0) | 111 (52.6) | 24 (11.4) | 0.712 |
Female | 76 (36.0) | 64 (30.3) | 12 (5.7) | |
Lauren classification | ||||
diffuse | 74 (35.1) | 58 (27.5) | 16 (7.6) | 0.290 |
intestinal | 113 (53.6) | 98 (46.4) | 15 (7.1) | |
mixed type | 24 (11.4) | 19 (9.0) | 5 (2.4) | |
Tumor size (UICC) | ||||
T0 | 4 (1.9) | 2 (0.9) | 2 (0.9) | 0.286 |
T1 | 2 (0.9) | 2 (0.9) | 0 (0) | |
T2 | 96 (45.5) | 81 (38.4) | 15 (7.1) | |
T3 | 73 (34.6) | 58 (27.5) | 15 (7.1) | |
T4 | 35 (16.6) | 31 (14.7) | 4 (1.9) | |
Tx | 1 (0.5) | 1 (0.5) | 0 (0) | |
Nodal status | ||||
N0 | 17 (8.1) | 10 (4.7) | 7 (3.3) | 0.006 |
N+ | 194 (91.9) | 165 (78.2) | 29 (13.7) | |
Capsule status of N+ cases | ||||
extra-capsular growth (ECG) | 70 (33.2) | 67 (31.8) | 3 (1.4) | 0.0003 |
intra-capsular growth (ICG) | 124 (58.8) | 98 (46.4) | 26 (12.3) | |
Distant metastasis | ||||
M0 | 137 (64.9) | 111 (52.6) | 26 (12.3) | 0.565 |
M1 | 58 (27.5) | 49 (23.2) | 9 (4.3) | |
Mx | 16 (7.6) | 15 (7.1) | 1 (0.5) | |
Tumor grade (WHO) | ||||
G1 | 2 (0.9) | 2 (0.9) | 0 (0) | 0.816 |
G2 | 31 (14.7) | 26 (12.3) | 5 (2.4) | |
G3 | 173 (82.0) | 144 (68.2) | 29 (13.7) | |
Gx | 5 (2.4) | 3 (1.4) | 2 (0.9) | |