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Table 3 Top biological functions of differentially expressed genes in canine iUC

From: Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq

Biological functions

Predicted activation state

Bias-corrected z-score

P-value

Cancer

Activated

2.051

2.08E-22

Epithelial cancer

Activated

2.834

5.93E-21

Neoplasia of epithelial tissue

Activated

2.221

7.60E-21

Tumorigenesis of tissue

Activated

2.21

1.10E-20

Abdominal neoplasm

Activated

2.057

2.58E-19

Proliferation of cells

Activated

4.057

3.16E-14

Cell movement of leukocytes

Activated

2.678

6.35E-10

Function of muscle

Inhibited

−2.234

9.06E-09

Mammary tumor

Activated

2.228

3.46E-08

Contractility of muscle

Inhibited

−3.244

4.22E-08

  1. Predicted activity based on gene expression values in canine iUC relative to healthy bladder. A z-score > 2 indicates activation, while a z-score < −2 indicates inhibition