Table 2 Top 30 upstream regulators of differentially expressed genes in canine iUC
From: Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq
Upstream regulator | Molecule type | Predicted activation state | Bias-corrected z-score | P-value of overlap |
|---|---|---|---|---|
PTGER2 | G-protein coupled receptor | Activated | 4.735 | 1.15E-17 |
ERBB2 | Kinase | Activated | 4.679 | 9.58E-17 |
Irgm1 | Other | Inhibited | −4.175 | 9.40E-16 |
IL6 | Cytokine | Activated | 3.46 | 3.32E-15 |
IL1B | Cytokine | Activated | 4.071 | 3.01E-13 |
CSF2 | Cytokine | Activated | 5.706 | 8.53E-13 |
CCND1 | Transcription regulator | Activated | 4.073 | 2.25E-12 |
TP53 | Transcription regulator | Inhibited | −2.977 | 1.41E-11 |
TNF | Cytokine | Activated | 4.168 | 1.57E-11 |
FOXM1 | Transcription regulator | Activated | 4.079 | 3.90E-09 |
HGF | Growth factor | Activated | 3.956 | 6.87E-09 |
E2F3 | Transcription regulator | Activated | 3.186 | 7.04E-09 |
FOXO1 | Transcription regulator | Activated | 3.643 | 1.21E-08 |
NFkB (complex) | Complex | Activated | 3.65 | 2.39E-08 |
IFNG | Cytokine | Activated | 3.536 | 2.72E-08 |
let-7 | MicroRNA | Inhibited | −4.119 | 3.16E-08 |
RABL6 | Other | Activated | 3.197 | 3.28E-08 |
JUN | Transcription regulator | Activated | 4.005 | 4.11E-08 |
IL1A | Cytokine | Activated | 3.265 | 1.94E-07 |
E2f | Group | Activated | 3.226 | 2.36E-07 |
Ap1 | Complex | Activated | 2.789 | 2.38E-07 |
IL22 | Cytokine | Activated | 3.199 | 4.46E-07 |
Vegf | Group | Activated | 3.595 | 4.97E-07 |
MAP2K3 | Kinase | Activated | 2.776 | 5.32E-07 |
NfkB-RelA | Complex | Activated | 2.107 | 5.68E-07 |
ERK1/2 | Group | Activated | 4.027 | 1.03E-06 |
EGFR | Kinase | Activated | 3.463 | 1.17E-06 |
IFI16 | Transcription regulator | Activated | 2.427 | 1.44E-06 |
E2F2 | Transcription regulator | Activated | 2.634 | 1.82E-06 |
ZFP36 | Transcription regulator | Inhibited | −3.606 | 2.12E-06 |