Table 4 Adverse events of IVC and IAC in the treatment of retinoblastoma
Trials | Treatment | Patients | Adverse Events |
|---|---|---|---|
Berry2012 | IVC | 7 | febrile neutropenia |
Kaliki2011 | IVC | 1 | pneumonia |
Fabian2017 | IVC | 6 | choroidal ischaemia |
| Â | Â | 4 | retinal detachments |
| Â | Â | 6 | nystagmus |
Friedman2016 | IVC | 8 | grade 3or 4 toxicity |
| Â | Â | 2 | infections (allergic reaction with urticaria) dehydration) |
Yousef2017 | IVC | 3 | rhegmatogenous retinal detachment |
Berry2017 | IVC | 2 | febrile neutropenia |
Munier2016 | IVC | 3 | occlusive choroidopathy |
Thampi2013 | IVC | 6 | infections (fever, acute otitis media, upper) respiratory tract infection) |
| Â | Â | 3 | vitreous hemorrhage |
| Â | Â | 2 | grade 4 neutropenia |
| Â | Â | 1 | cataract |
Brichard 2002 | IVC | 9 | non-specific gastrointestinal toxicity |
| Â | Â | 8 | cytopenias |
| Â | Â | 8 | fever |
Gobin2011 | IAC | 6 | allergic reaction |
| Â | Â | 3 | cataract |
| Â | Â | 29 | neutropenia |
| Â | Â | 1 | fever |
Abramson2016 | IAC | 39 | grade 3 or 4 neutropenia |
| Â | Â | 5 | allergy-type reaction |
| Â | Â | 4 | grade 3 or 4 thrombocytopenia |
| Â | Â | 4 | fever |
| Â | Â | 6 | retinal or choroidal vascular occlusions |
| Â | Â | 5 | phthisis |
| Â | Â | 4 | vitreous hemorrhage |
Shields2014 | IAC | 4 | vitreous hemorrhage |
| Â | Â | 5 | artery obstruction |
| Â | Â | 4 | partial choroidal ischemia |
Fabian2017 | IAC | 6 | Nystagmus |
Abramson2008 | IAC | 3 | lids edema |
| Â | Â | 3 | conjunctiva hyperemia |
| Â | Â | 1 | radiationlike retinopathy |
| Â | Â | 1 | neutropenia |
Abramson2010 | IAC | 9 | grade 3 neutropenia |
| Â | Â | 1 | grade 4 neutropenia |
Tuncer2016 | IAC | 9 | chorioretinal atrophy |
| Â | Â | 5 | noted retinal detachment |
| Â | Â | 1 | vitreous haemorrhage |