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Table 1 Correlation between NLRP3 expression and clinicopathological features, IL-1β expression in patients with OSCC (n = 77)

From: NLRP3 promotes tumor growth and metastasis in human oral squamous cell carcinoma

Characteristics n(77) NLRP3 expression P-valuea
negative (20) weak(24) positive (33)
n(%) n(%) n(%)
Age(years)      0.436
 ≤ 60 40 10 (25) 15 (37.5) 15 (37.5)  
 >60 37 10 (27) 9 (24.3) 18 (48.7)  
Sex      0.718
 Male 57 15 (26.3) 19 (33.3) 23 (40.4)  
 Female 20 5 (25) 5 (25) 10 (50)  
Smoking statusb      0.491
 Current/former 36 8 (22.2) 10 (27.8) 18 (50)  
 Never 41 12 (29.3) 14 (34.1) 15 (36.6)  
Alcohol usec      0.561
 Yes 26 5 (19.2) 8 (30.8) 13 (50)  
 No 51 15 (29.4) 16 (31.4) 20 (39.2)  
Location      0.403
 Gingiva 23 4 (17.4) 6 (26.1) 13 (56.5)  
 Tongue 31 11 (35.5) 11 (35.5) 9 (29)  
 Floor of mouth 10 1 (10) 4 (40) 5 (50)  
 Buccal 13 4 (30.7) 3 (23.1) 6 (46.2)  
AJCC stage      0.018*
 I 21 10 (47.6) 8 (38.1) 3(14.3)  
 II 41 8 (19.5) 11(26.8) 22 (53.7)  
 III 15 2 (13.3) 5 (33.3) 8 (53.4)  
T stage      0.015*
 T1 9 5 (55.6) 3 (33.3) 1 (11.1)  
 T2 24 10 (43.5) 6 (26.1) 8(30.4)  
 T3 28 3 (10.7) 10(35.7) 15 (53.6)  
 T4 16 2 (12.5) 5 (31.2) 9(56.3)  
N stage      0.008**
 N0 39 15(38.5) 15 (38.5) 9 (23)  
 N1 23 3 (13) 6 (26.1) 14 (60.9)  
 N2 15 2 (13.3) 3 (20) 10 (66.7)  
IL-1β expression      0.004**
 Negative 21 12(57.2) 4(19) 5(23.8)  
 Weak 21 4(19) 7(33.3) 10(47.7)  
 Positive 35 4(11.4) 13(37.1) 18(51.5)  
  1. aP-values are based on chi-squared or Fisher’s exact test. P < 0.05 indicates a significant association among the variables. (*P<0.05, **P<0.01)
  2. bFormer/current smokers defined as at least a one pack-year history of smoking
  3. cAlcohol intake was defined as current alcohol intake of more than one drink per day for 1 year. Others were classified as no alcohol intake