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Table 4 Performance of 1-sample and 2-sample FIT for advanced neoplasia at different hemoglobin concentration cutoffs

From: Performance of a quantitative fecal immunochemical test for detecting advanced colorectal neoplasia: a prospective cohort study

   % positive Sensitivity Specificity PPV NPV
Test Threshold (ng/ml)   Est. LL UL Est. LL UL Est. LL UL Est. LL UL
1-FIT 50 7.58 22.6 17.0 28.3 93.7 92.7 94.6 22.9 17.2 28.5 93.6 92.7 94.5
2-FIT 50 11.99 29.7 23.6 35.9 89.5 88.3 90.7 19.0 14.8 23.2 93.9 92.9 94.8
1-FIT 75 5.09 16.5 11.5 21.5 95.9 95.1 96.6 24.8 17.7 32.0 93.3 92.3 94.2
2-FIT 75 8.09 23.1 17.4 28.8 93.1 92.2 94.1 21.9 16.5 27.3 93.6 92.7 94.6
1-FIT 100 4.19 14.2 9.5 18.8 96.6 95.9 97.3 25.9 17.9 33.8 93.2 92.2 94.1
2-FIT 100 6.50 19.3 14.0 24.7 94.6 93.7 95.5 22.8 16.7 28.9 93.4 92.4 94.4
1-FIT 125 3.61 13.7 9.1 18.3 97.2 96.6 97.9 29.0 20.1 37.9 93.2 92.2 94.1
2-FIT 125 5.42 18.4 13.2 23.6 95.7 94.9 96.5 26.0 19.0 33.0 93.4 92.5 94.4
1-FIT 150 3.03 12.3 7.9 16.7 97.7 97.2 98.3 31.0 21.1 40.8 93.1 92.1 94.0
2-FIT 150 4.66 17.5 12.3 22.6 96.4 95.7 97.1 28.7 20.9 36.5 93.4 92.4 94.3