Table 4 Performance of 1-sample and 2-sample FIT for advanced neoplasia at different hemoglobin concentration cutoffs
| Â | Â | % positive | Sensitivity | Specificity | PPV | NPV | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Test | Threshold (ng/ml) | Â | Est. | LL | UL | Est. | LL | UL | Est. | LL | UL | Est. | LL | UL |
1-FIT | 50 | 7.58 | 22.6 | 17.0 | 28.3 | 93.7 | 92.7 | 94.6 | 22.9 | 17.2 | 28.5 | 93.6 | 92.7 | 94.5 |
2-FIT | 50 | 11.99 | 29.7 | 23.6 | 35.9 | 89.5 | 88.3 | 90.7 | 19.0 | 14.8 | 23.2 | 93.9 | 92.9 | 94.8 |
1-FIT | 75 | 5.09 | 16.5 | 11.5 | 21.5 | 95.9 | 95.1 | 96.6 | 24.8 | 17.7 | 32.0 | 93.3 | 92.3 | 94.2 |
2-FIT | 75 | 8.09 | 23.1 | 17.4 | 28.8 | 93.1 | 92.2 | 94.1 | 21.9 | 16.5 | 27.3 | 93.6 | 92.7 | 94.6 |
1-FIT | 100 | 4.19 | 14.2 | 9.5 | 18.8 | 96.6 | 95.9 | 97.3 | 25.9 | 17.9 | 33.8 | 93.2 | 92.2 | 94.1 |
2-FIT | 100 | 6.50 | 19.3 | 14.0 | 24.7 | 94.6 | 93.7 | 95.5 | 22.8 | 16.7 | 28.9 | 93.4 | 92.4 | 94.4 |
1-FIT | 125 | 3.61 | 13.7 | 9.1 | 18.3 | 97.2 | 96.6 | 97.9 | 29.0 | 20.1 | 37.9 | 93.2 | 92.2 | 94.1 |
2-FIT | 125 | 5.42 | 18.4 | 13.2 | 23.6 | 95.7 | 94.9 | 96.5 | 26.0 | 19.0 | 33.0 | 93.4 | 92.5 | 94.4 |
1-FIT | 150 | 3.03 | 12.3 | 7.9 | 16.7 | 97.7 | 97.2 | 98.3 | 31.0 | 21.1 | 40.8 | 93.1 | 92.1 | 94.0 |
2-FIT | 150 | 4.66 | 17.5 | 12.3 | 22.6 | 96.4 | 95.7 | 97.1 | 28.7 | 20.9 | 36.5 | 93.4 | 92.4 | 94.3 |