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Table 2 Clinicopathologic characteristics and immunohistochemical expression of NKX2.5 of the PTC tumor (N = 51). Data were analyzed by Fisher’s exact test

From: NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells

Variable Category Score of NKX2.5
Negative No. (%) Low
No. (%)
High
No. (%)
p Value
NKX2.5 expression Negative 24 (47.1%) 0 (0.0%) 0 (0.0%)  
Positive 0 (0.0%) 16 (31.4%) 11 (21.6%)
Outcome Without recurrence or persistence 7 (13.7%) 6 (11.8%) 8 (15.7%) 0.013
Recurrence 3 (5.9%) 6 (11.8%) 0 (0.0%)
Persistence 14 (27.5%) 4 (7.8%) 3 (5.9%)
Pathological stage of primary tumor size (pT) pT1 and pT2 14 (27.5%) 3 (5.9%) 6 (11.8%) 0.029
pT3 and pT4 10 (19.6%) 13 (25.5%) 4 (7.8%)
pTx 0 (0.0%) 0 (0.0%) 1 (2.0%)
  1. Negative score of NKX2.5 was related to persistence (p = 0.013) and pathological stage of primary tumor sizes pT1 and pT2 (p = 0.029)