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Table 2 Associations between NUDT15 c.415C > T and risk of leukopenia, hepatotoxicity and therapy interruption

From: Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?

  NUDT15 (rs116855232, c.415C > T) Dominant model
CC(n = 74) CT(n = 29) TT(n = 2) P value OR (95% CI)
Leukopenia (WBC < 2 × 109/L)
 No 63 19 0 0.009
 Yes 11 10 2 3.617 (1.377–9.051)
Early-onset leukopenia (WBC < 2 × 109/L)
 No 70 20 0 3.75 × 10−4
 Yes 4 9 2 9.63(2.764–33.514)
Hepatotoxicity (AST/ALT> 500 IU/L)
 No 70 27 2 0.883
 Yes 4 2 0 1.207 (0.209–6.957)
Therapy interruption
 No 58 27 2 0.077
 Yes 16 2 0 0.25 (0.054–1.162)
  1. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated using logistic regression
  2. Early-onset leukopenia was defined as leukopenia occurrence during the first 60 days of the maintenance therapy
  3. Dominant model (CT + TT vs CC)
  4. Abbreviations: WBC white blood cells, ALT alanine aminotransferase, AST aspartate aminotransferase