Fig. 1
From: Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells
CICs are resistant to in vivo vaccine-mediated antitumor immune responses. Mice (n = 8) were subcutaneously injected with 200,000 TC-1 non-CICs or CICs. Other mice were vaccinated (n = 12) with HPV-16 E749–57 peptide and subcutaneously injected with non-CICs or CICs. Tumor-free survival was assessed. TC-1 non-CICs (closed circles), CICs (open circles), non-CICs vaccinated (closed triangles), or CICs vaccinated (open triangles). a Tumor-free survival was delayed in vaccinated mice receiving non-CICs compared to unvaccinated mice receiving non-CICs. b No difference in tumor-free survival was seen for CICs comparing vaccinated to unvaccinated mice. c Frequency of tumor-infiltrating CD8+ cells is greater in non-CICs (n = 4) than in CICs (n = 5) derived tumors. Error bars are standard deviation. **P = 0.007, *P = 0.035