Fig. 5

Evaluation of the Yin Yang gene expression ratio (YMR) model using the common genes. a Defining the Yin and Yang genes from the 220 common genes using the 1141 METABRIC samples data. The rows are the 220 genes that were shared by at least two signatures and the columns are the 1141 samples. The genes that showed consistently higher expression in normal breast tissue samples (in blue) and relative consistently lower expression in various tumour subtypes were selected as Yang genes (red). The genes that showed consistently lower expression in normal samples and higher expression in tumour samples were selected as Yin genes (green). The PAM50 subtypes were indicated by colour bars. b The YMR-all signature model developed by the selected Yin and Yang genes was tested by Kaplan-Meier survival analysis using two data sets