Fig. 11From: C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cellsProposed model for the role of c-Cbl in tamoxifen resistance of HER2-overexpressing breast cancer cells. In HER2-overexpressing breast cancer cells, ER-c-Src-HER2 complex formation results in HER2 signaling pathway activation and tamoxifen resistance. c-Cbl reduces ER-c-Src-HER2 complex formation by inhibiting lipid rafts and restores the sensitivity to tamoxifenBack to article page