Fig. 4

Differentially expressed genes from involved in cholesterol regulation, uptake, efflux and transport. Results from individual cohorts as well as the seven-study-cohort can be found in Additional file 1: Fig. S5. a The figure shows –log10 p-values multiplied by 1 for upregulated genes, and − 1 for downregulated genes. All p-values presented are corrected for multiple testing using the total number of 25,964 unique gene identifiers from all cohorts. Results from individual cohorts as well as the seven-study-cohort can be found in Additional file 1: Figure S4. b The schematic representation illustrates the cellular function of the selected genes, with down- and upregulated genes color-coded in blue and red, respectively. The strength of the color corresponds to the degree of down- or upregulation