Table 2 Univariate and multivariate models for OS with BM in mTNBC patients (n = 127)

Age

0.55

  ≤ 40

29

6.4

1.7–11.1

  > 40

98

7.3

6.1–8.5

DFI

0.33

  ≤ 1 y

31

7.6

4.7–10.5

  > 1 y

76

7.6

4.5–11.7

 IV

20

5.4

KPS

0.000

0.07

 70–100

109

7.6

4.7–10.4

1.81

 40–60

18

1.7

0.2–3.4

Recurrent BM

0.008

0.01

 First

32

17.3

9.2–25.3

2.21

1.18–4.17

 Subsequent

95

6.3

4.5–8.0

Number of intracranial metastases

0.002

0.001

  > 3

58

5.4

2.1–8.7

2.37

1.47–3.80

  ≤ 3

69

10.2

6.3–14.1

Symptomatic brain metastasis

0.02

0.01

 Presence

76

5.5

2.8–8.2

1.92

1.13–3.27

 Absence

51

8.7

3.0–16.7

Meninges involvement

0.01

0.48

 Yes

14

3.2

0.9–5.4

1.32

0.61–2.83

 No

113

7.6

4.8–10.3

Brain-directed treatment

0.001

0.002

 Not performed

29

3.7

0.2–7.7

2.30

1.32–3.92

 Performed

98

9.5

6.3–12.7

Extracranial metastasis^a

0.002

0.02

 Under-control

37

9.8

5.8–13.8

1.78

1.13–2.92

 Out-of-control

65

3.6

2.2–4.9