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Table 2 Univariate and multivariate models for OS with BM in mTNBC patients (n = 127)

From: Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer

   Univariate Multivariate
Factor No. Median 95% CI P HR 95% CI P
Age     0.55    
  ≤ 40 29 6.4 1.7–11.1     
  > 40 98 7.3 6.1–8.5     
DFI     0.33    
  ≤ 1 y 31 7.6 4.7–10.5     
  > 1 y 76 7.6 4.5–11.7     
 IV 20 5.4      
KPS     0.000    0.07
 70–100 109 7.6 4.7–10.4   1.81   
 40–60 18 1.7 0.2–3.4     
Recurrent BM     0.008    0.01
 First 32 17.3 9.2–25.3   2.21 1.18–4.17  
 Subsequent 95 6.3 4.5–8.0     
Number of intracranial metastases     0.002    0.001
  > 3 58 5.4 2.1–8.7   2.37 1.47–3.80  
  ≤ 3 69 10.2 6.3–14.1     
Symptomatic brain metastasis     0.02    0.01
 Presence 76 5.5 2.8–8.2   1.92 1.13–3.27  
 Absence 51 8.7 3.0–16.7     
Meninges involvement     0.01    0.48
 Yes 14 3.2 0.9–5.4   1.32 0.61–2.83  
 No 113 7.6 4.8–10.3     
Brain-directed treatment     0.001    0.002
 Not performed 29 3.7 0.2–7.7   2.30 1.32–3.92  
 Performed 98 9.5 6.3–12.7     
Extracranial metastasisa     0.002    0.02
 Under-control 37 9.8 5.8–13.8   1.78 1.13–2.92  
 Out-of-control 65 3.6 2.2–4.9     
  1. a103 patients died