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Table 1 Clinical studies describing women with radiogenic angiosarcoma of the breast

From: Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

Author Year Study type Number of cases (n) Incidence Single/Multiple lesions (n/n) Time (m) since breast RXT (n) Area of initial RXT (n) Dosage (Gray) at initial RXT (n)
Fodor [4] 2006 CS 8 4/4 75 Br (3); Br + Ax (5) 46 (1); 48 (1); 50 (6)
Marchal [5] 1999 COS 9 9/18115 74 Br (9) 50 + B (8);45 (1)
D’Angelo [6] 2013 COS 79 84
Strobbe [9] 2016 COS 21 21/16500 14/7 74 Br (21) 50 + B (6); 44 + B (1);45 + B (1); 46 + B (1);45 + BT (2);50 + BT (10)
Smith [12] 2014 CS 14 92 Br (14) 60 (14)
Iqbal [15] 2016 CR 1
Jayalakshmy [16] 2012 CS 2 0/2 36;24
Vertse [17] 2010 CR 1 120
Des Guetz [18] 2009 CS 3
West [19] 2005 COS 4 4/423 2/2 131;109;52;119 Br (4) 45 + B (1);50 + B (3)
Rao [20] 2003 CS 3 0/3 168;48;96 Br (3) 40 + B (1);50 (2)
Seo [13] 2003 CR 1 1/0 60 Br 50 (1)
Polgár [21] 2001 COS 2 2/5100 1/1 72;100 Br (1);CW (1) 50 (1);45 (1)
Vesoulis [22] 2000 CR 1 0/1 96 Br
Layfield [23] 1997 CR 1 Br
Sole [24] 1996 COS 1 1/3120 172 Br 50 (1)
Wijnmaalen [25] 1993 CR 3 3/0 66;77;84 Br (1); Br + Ax (1) 45 + B (2);50 + B (1)
Shaikh [14] 1988 CR 1 48 Br
Segal [26] 1988 CR 1
Otis [27] 1986 CS 2 2/0 37;37 CW + SC + IMA (2) 60 (1);50 (1)
Lo [28] 1985 CR 1 1/0 72 CW
Armengot-Carbó [29] 2012 CR 1 0/1 36 CW
Fernández Ortega [30] 2006 CS 2 1/1 48;53 Br (2) 50 + B (2)
Di Tommaso [31] 2003 CR 1 1/0 108 Br
Friedrich [32] 1996 CR 1 1/0 108 Br 50
Colville [33] 2000 CR 1 0/1 92 Br 50
Hogewind [34] 2004 CS 2 2/0 84;60 Br (2)
Williams [35] 1999 CR 1 1/0 44 Br 40 + B
Mermershtain [36] 2002 CR 1 0/1 47 Br 50
Deutsch [37] 2003 CR 1 1/0 18 Br 50 + B
Pfeiffer [38] 2006 CR 1 0/1 72 Br + Ax 40 + B
Griffa [39] 2000 CR 1 0/1
Kariniemi [40] 1998 CR 1
Hildebrandt [41] 2001 CR 1 0/1 66
Esler-Brauer [7] 2007 CR 1 1/0 60
Catena [42] 2006 CR 1 0/1 57 Br 50 + B
Moe [43] 2007 CR 1 0/1 30 Br 45
Lamblin [44] 2001 CS 4
Hodgson [45] 2007 COS 31 31/220000 15/16 62
Weed [46] 2008 CR 1
Bolin [47] 1996 CR 1 120
Soldić [48] 2009 CR 1 1/0 40 45 + B
Horevoets [49] 2013 CR 1 1/0
Andrews [50] 2010 CR 1 0/1 51 MSBT 34
Kajo [51] 2007 CR 1 1/0 96 50 + B
Nambisan [52] 2008 CR 1
Zucali [53] 1994 COS 3 3/3295 3/0 18;59;41 Br (3) 50 + B (2); 45 + B (1)
Aydogdu [54] 1996 CR 1 0/1 60
Del Mastro [55] 1994 CR 1 40
Weber [56] 1995 CS 3 2/1 60 (2);72 Br + Ax (1);Br + Ax+SC + IMA (1);Br + IMA + SC (1) 50 + B (1);50 (2)
Majeski [57] 2000 CR 1 0/1 63 Br 50
Wiebringhaus [58] 2015 CS 3 2/1 72;120;36 Br (3)
Bonetta [59] 1995 CR 1 1/0 62 Br
Nakamura [60] 2007 CR 1 0/1 120 Br 50 + B
Anania [61] 2002 CR 1 1/0 120 Br
Barbosa [62] 2015 CR 1 1/0 120 Br
Nestle-Krämling 622] 2011 CS 4 1/0 120 Br
Billings [64] 2004 CS 27 11/13a 66 Br (27) 47 + B (11);50 (2);45 (2)b
Sessions [65] 1992 CR 1 54 Br
Zafar [66] 2012 CR 1 0/1 72 Br 50
Navarro Cecilia [67] 2015 CR 1 0/1 84 Br 50 + B
Uryvaev [68] 2015 CS 6 5/1 110 Br (5);Br + Ax (1) 50 + B (1);61 (1);45 (1);40 + B (1);50 + B (1)c
Gennaro [69] 2010 CS 9 96
Feigenberg [8] 2002 CS 3 0/3 48 (2);60 Br 50 (1);50 + B (2)
Hui [70] 2012 CS 8 84 (8)
Taat [71] 1992 CR 1 66 Br
Adhikari [72] 2002 CR 1 1/0 204 Br 50
Azizun-Nisa [73] 2013 CS 3 2/1
Hanasono [74] 2005 CR 1 0/1 80 CW + SC
Mocerino [75] 2016 CR 1 1/0 94 Br 60
Scow [76] 2010 CR 1 1/0 94 Br 60
Zemanova [77] 2014 CR 1 0/1 144 Br 46 + B
Moskaluk [78] 1992 CR 1 1/0 96 Br 20 + BT
Plichta [79] 2017 CR 1 0/1 60 Br
Boyan [80] 2014 CR 1 0/1 60 Br
Pooled Analysis 307 1/3754 87/75 77.2
  1. Abbreviations: Ax axilla, B boost, Br breast, BT brachytherapy, COS cohort study, CR case report, CS case series, CW chest wall, IMA internal mammary lymph nodes, m months, MSBT Mammosite® brachytherapy, n number of cases, RXT radiotherapy, SC supraclavicular lymph nodes, TCG telecobalt-gamma
  2. a3 cases unknown
  3. b12 cases unknown
  4. c1 case unknown