Table 6 Clinical characteristics of BC patients with high cumulative genetic risk score (≥4 risk alleles)
Characteristics | BC patients | |
|---|---|---|
with ≥4 risk alleles | with < 4 risk alleles | |
Mean age at diagnosis (yrs.) | ||
53 | 54 | |
Histological subtype of breast cancer No. (%) | ||
Ductale | 55 (77.5) | 136 (55.7) |
Lobulare | 6 (8.5) | 29 (11.9) |
Tubular carcinoma | 2 (2.8) | 13 (5.3) |
Ductalolobular | – | 11 (4.5) |
Tubuloductale | 6 (8.5) | – |
Solidum | 1 (1.4) | 1(0.4) |
Mucinosum | – | 2 (0.8) |
Metaplasticum | 1 (1.4) | 1(0.4) |
Unknown | – | 51(20.9) |
Tumor grade No. (%) | ||
G1 | – | 31 (12.7) |
G2 | 33 (46.5) | 58 (23.8) |
G3 | 13 (18.3) | 42 (17.2) |
Gx | 25 (35.2) | 50 (20.5) |
Unknown grade | – | 63 (25.8) |
Family history of cancers No. (%) | ||
Positive | 18 (25.4) | 83 (34) |
Negative | 53 (74.6) | 118 (48.4) |
Unknown status | – | 43 (17.6) |
T stage at diagnosis No. (%) | ||
T1 | 16 (22.5) | 27 (11.1) |
T2 | 36 (50.7) | 107 (43.9) |
T3 | 10 (14.1) | 27 (11.1) |
T4 | 9 (12.7) | 18 (7.4) |
Tx | – | 7 (2.9) |
Unknown T stage | – | 58 (23.6) |
ERstatus No. (%) | ||
ER positive | 25 (35.2) | 127 (52) |
ER negative | 42 (59.2) | 60 (24.6) |
ER unknown | 4 (5.6) | 57 (23.4) |
PgR status No. (%) | ||
PgR positive | 30 (42.3) | 124 (50.8) |
PgR negative | 39 (54.9) | 62 (25.4) |
PgR unknown | 2 (2.8) | 58 (23.8) |