Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population

BMC Cancer

Table 4 Allele frequency distribution and logistic regression analysis of the H2AFX and MRE11 SNPs in BC

SNP/Alleles	No. of alleles (%)		P value	OR	95% CI
SNP/Alleles	C	BC	P value	OR	95% CI
rs7759
A	743 (72)	401 (63.6)		1^a
G	287 (28)	229 (36.4)	0.0003 (0.0018) ^b	1.47	1.19 to 1.82
rs8551
C	675 (65.6)	371 (58.9)		1^a
T	355 (34.4)	259 (41.1)	0.006 (0.018) ^b	1.33	1.09 to 1.64
rs643788
T	672 (65.2)	379 (60)		1^a
C	358 (34.8)	251(39.8)	0.16	1.16	0.94 to 1.43
rs2509049
C	673 (65.3)	373 (59.3)		1^a
T	357 (34.6)	257 (42.2)	0.012 (0.024) ^b	1.3	1.06 to 1.59
rs1061956
A	1021(99.1)	627 (99.5)		1^a
G	9 (0.9)	3 (0.5)	0.35	0.54	0.15 to 2.01
rs2155209
T	717 (69.6)	427 (67.8)		1^a
C	313 (30.4)	203 (32.2)	0.43	1.09	0.88 to 1.35

^a = reference category; OR (95% CI) = odds ratio (95% confidence interval); ^b = result statistically significant after Benjamini-Hochberg correction; C = controls, BC = breast cancer patients
Bold data are statistically significant

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