Fig. 4
From: Small cell and non small cell lung cancer form metastasis on cellular 4D lung model
Breast cancer cell lines on the cellular 4D lung model. Primary tumors were formed in a bronchocentric fashion on cellular lung upon MCF7 (a) and MDAMB231 (e) cell seeding though no distinct nodules appeared. Human mitochondrial IHC staining clearly shows the presence of a tumor formed by human breast cancer cells in a rat lung after 15 days of culture in a bioreactor. Low and high power H&E staining indicates the presence of a microscopic tumor with distinctive histology based of the cell type seeded. MCF7 cells formed solid gland carcinoma with large epithelioid cells and prominent nucleoli (c and d). MDAM231 cells formed large confluent primary tumors with poorly differentiated malignant carcinoma having spindle cell morphology (g and h)