Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients

Table 1 Five normal tissue complication probability (NTCP) models from four published and present study

NTCP model	b	constant	OR	95% CI	AUC
Boomsma et al.		0.011			0.85 (95% CI: 0.78–0.92)
D_mean	0.062		1.064/Gy	1.029–1.101
Thyroid volume	−0.19		0.826/cm³	0.740–0.921
Cella et al. model 1		−1.83			0.865 (95% CI: 0.793–0.945)
V30%	0.038		1.039	1.019–1.059
Gender	−2.32		0.098	0.019–0.500
Cella et al. model 2		1.94			0.874 (95% CI: 0.750–0.951)
V30 cc	0.26		1.297	1.087–1.547
Gender	−2.21		0.110	0.021–0.580
Thyroid volume	−0.27		0.763	0.615–0.947
Rønjom et al.		−2.019			NA
D_mean	0.0821		1.12/Gy	1.07–1.20
Thyroid volume	−0.189		0.75/cm³	0.64–0.85
Luo et al.		−2.695			0.793(95% CI: 0.725–0.851)
V₅₀	0.050		1.051	1.027–1.076
P_max	−0.026		0.974	0.956–0.993
Gender	1.280		3.598	1.461–8.865
Chemotherapy	2.902		18.213	1.920–172.766

Abbreviation: OR odds ratio, CI confidence interval, AUC the area under the receiver operating characteristic curve, NA not available in original article

ISSN: 1471-2407