From: The impact of pharmacokinetic gene profiles across human cancers
 | Univariate | Multivariate | ||||||
---|---|---|---|---|---|---|---|---|
Rulea | Genomics features | Low-risk (N) | High-risk (N) | High-risk (%) | HR [95% CI] | p-value | HR [95% CI] | p-value |
Export | 1 | 2749 | 109 | 3.8 | 1.49 [1.09, 2.05] | 1.2 × 10−2 | 1.49 [1.13, 1.96] | 4.7 × 10− 3 |
Import | 1 | 2777 | 81 | 2.8 | 0.90 [0.61, 1.33] | 6.0 × 10−1 | 1.00 [0.76, 1.32] | 1.0 × 100 |
Metabolism | 1 | 2642 | 216 | 7.6 | 1.26 [0.94, 1.69] | 1.3 × 10−1 | 1.12 [0.85, 1.48] | 4.2 × 10− 1 |
Metabolismb | 1 | 2809 | 49 | 1.7 | 1.74 [1.09, 2.77] | 2.1 × 10− 2 | 1.73 [1.31, 2.28] | 9.3 × 10− 5 |
Target | 1 | 2780 | 78 | 2.7 | 1.12 [0.76, 1.66] | 5.6 × 10− 1 | 1.07 [0.81, 1.41] | 6.3 × 10− 1 |
Any-Hit | 3 | 2530 | 328 | 11.5 | 1.21 [0.94, 1.55] | 1.4 × 10− 1 | 1.17 [0.88, 1.53] | 2.8 × 10− 1 |
Any-PK-Hit | 2 | 2660 | 198 | 6.9 | 1.26 [0.97, 1.64] | 7.8 × 10−2 | 1.27 [0.96, 1.67] | 9.4 × 10− 2 |
Efficacy Model | 2 | 2715 | 143 | 5.0 | 1.41 [1.06, 1.88] | 1.9 × 10−2 | 1.47 [1.11, 1.93] | 6.3 × 10− 3 |