Fig. 4

High expression of drug export genes for administered therapies is associated with poorer overall survival. a Our pan-cancer analysis revealed a statistically significant association between high expression levels of genes known to export therapies administered to each patient and overall survival. Pan-cancer cohort size is indicated (N) along with the number of patients affected (M) Varying the expression threshold used identified a tradeoff between the number of patients affected and HR magnitude. A distribution diagram highlights the analogous region considered for each model. Models are summarized by p-value, HR, and bounds of the 95% confidence interval. Meta-analyses are summarized by a diamond centered on the HR and its width extending to the confidence interval bounds. b For the Z ≥ 2 criteria, per-cancer models are summarized in a Forest plot. For each cancer type, the HR is marked and scaled by M; a line extends to the confidence interval bounds