Table 3 Diagnostic value of five single microRNAs and their combinations
From: Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer
MicroRNA(s) | Sensitivity (%) | Specificity (%) | AUC (95% CI) | Cut-off value | Youden index |
|---|---|---|---|---|---|
miR-18a | 65.0 | 69.5 | 0.731 (0.655, 0.807) | 2.201 | 0.345 |
miR-19a | 80.0 | 75.6 | 0.821 (0.757, 0.885) | 2.072 | 0.556 |
miR-21 | 77.5 | 42.7 | 0.590 (0.502, 0.678) | 2.133 | 0.202 |
miR-92a | 95.0 | 56.1 | 0.817 (0.753, 0.881) | 3.533 | 0.511 |
miR-199a | 97.5 | 36.6 | 0.684 (0.602, 0.766) | 3.530 | 0.341 |
miR-421 | 93.8 | 20.7 | 0.556 (0.467, 0.644) | 1.525 | 0.145 |
miR-18a + miR-19a | 76.3 | 80.5 | 0.833 (0.772, 0.894) | 3.600 | 0.567 |
miR-18a + miR-21 | 55.0 | 80.5 | 0.729 (0.652, 0.806) | 2.454 | 0.355 |
miR-18a + miR-92a | 96.3 | 58.5 | 0.823 (0.760, 0.885) | 6.901 | 0.548 |
miR-18a + miR-199a | 78.8 | 58.5 | 0.746 (0.672, 0.820) | 3.865 | 0.373 |
miR-19a + miR-21 | 78.8 | 75.6 | 0.820 (0.756, 0.884) | 2.086 | 0.544 |
miR-19a + miR-92a | 91.3 | 61.0 | 0.850 (0.794, 0.907) | 6.898 | 0.522 |
miR-19a + miR-199a | 80.0 | 72.0 | 0.819 (0.755, 0.883) | 3.580 | 0.520 |
miR-21 + miR-92a | 91.3 | 63.4 | 0.820 (0.757, 0.884) | 7.300 | 0.547 |
miR-21 + miR-199a | 93.8 | 36.6 | 0.681 (0.600, 0.762) | 3.661 | 0.303 |
miR-92a + miR-199a | 81.3 | 70.7 | 0.818 (0.754, 0.881) | 7.272 | 0.520 |
miR-18a + miR-19a + miR-21 | 75.0 | 81.7 | 0.835 (0.774, 0.896) | 3.323 | 0.567 |
miR-18a + miR-19a + miR-92a | 72.5 | 85.4 | 0.857 (0.801, 0.912) | 7.780 | 0.579 |
miR-18a + miR-19a + miR-199a | 78.8 | 76.8 | 0.836 (0.775, 0.896) | 4.025 | 0.556 |
miR-18a + miR-21 + miR-92a | 93.8 | 62.2 | 0.828 (0.766, 0.890) | 6.884 | 0.559 |
miR-18a + miR-21 + miR-199a | 81.3 | 57.3 | 0.746 (0.672, 0.820) | 3.845 | 0.386 |
miR-18a + miR-92a + miR-199a | 98.8 | 52.4 | 0.826 (0.764, 0.888) | 6.174 | 0.512 |
miR-19a + miR-21 + miR-92a | 81.3 | 72.0 | 0.859 (0.805, 0.913) | 7.140 | 0.532 |
miR-19a + miR-21 + miR-199a | 80.0 | 72.0 | 0.820 (0.756, 0.883) | 3.410 | 0.520 |
miR-19a + miR-92a + miR-199a | 72.5 | 81.7 | 0.857 (0.802, 0.912) | 7.188 | 0.542 |
miR-21 + miR-92a + miR-199a | 92.5 | 62.2 | 0.820 (0.757, 0.884) | 6.830 | 0.547 |
miR-18a + miR-19a + miR-21 + miR-92a | 82.5 | 73.2 | 0.861 (0.807, 0.915) | 6.938 | 0.557 |
miR-18a + miR-19a + miR-21 + miR-199a | 75.0 | 80.5 | 0.836 (0.775, 0.897) | 4.022 | 0.555 |
miR-18a + miR-19a + miR-92a + miR-199a | 77.5 | 79.3 | 0.861 (0.806, 0.915) | 6.876 | 0.568 |
miR-18a + miR-21 + miR-92a + miR-199a | 97.5 | 58.5 | 0.830 (0.768, 0.891) | 6.166 | 0.560 |
miR-19a + miR-21 + miR-92a + miR-199a | 80.0 | 75.6 | 0.862 (0.808, 0.915) | 6.491 | 0.556 |
miR-18a + miR-19a + miR-21 + miR-92a + miR-199a | 87.5 | 69.5 | 0.867 (0.814, 0.920) | 5.983 | 0.570 |