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Table 3 Diagnostic value of five single microRNAs and their combinations

From: Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

MicroRNA(s) Sensitivity (%) Specificity (%) AUC (95% CI) Cut-off value Youden index
miR-18a 65.0 69.5 0.731 (0.655, 0.807) 2.201 0.345
miR-19a 80.0 75.6 0.821 (0.757, 0.885) 2.072 0.556
miR-21 77.5 42.7 0.590 (0.502, 0.678) 2.133 0.202
miR-92a 95.0 56.1 0.817 (0.753, 0.881) 3.533 0.511
miR-199a 97.5 36.6 0.684 (0.602, 0.766) 3.530 0.341
miR-421 93.8 20.7 0.556 (0.467, 0.644) 1.525 0.145
miR-18a + miR-19a 76.3 80.5 0.833 (0.772, 0.894) 3.600 0.567
miR-18a + miR-21 55.0 80.5 0.729 (0.652, 0.806) 2.454 0.355
miR-18a + miR-92a 96.3 58.5 0.823 (0.760, 0.885) 6.901 0.548
miR-18a + miR-199a 78.8 58.5 0.746 (0.672, 0.820) 3.865 0.373
miR-19a + miR-21 78.8 75.6 0.820 (0.756, 0.884) 2.086 0.544
miR-19a + miR-92a 91.3 61.0 0.850 (0.794, 0.907) 6.898 0.522
miR-19a + miR-199a 80.0 72.0 0.819 (0.755, 0.883) 3.580 0.520
miR-21 + miR-92a 91.3 63.4 0.820 (0.757, 0.884) 7.300 0.547
miR-21 + miR-199a 93.8 36.6 0.681 (0.600, 0.762) 3.661 0.303
miR-92a + miR-199a 81.3 70.7 0.818 (0.754, 0.881) 7.272 0.520
miR-18a + miR-19a + miR-21 75.0 81.7 0.835 (0.774, 0.896) 3.323 0.567
miR-18a + miR-19a + miR-92a 72.5 85.4 0.857 (0.801, 0.912) 7.780 0.579
miR-18a + miR-19a + miR-199a 78.8 76.8 0.836 (0.775, 0.896) 4.025 0.556
miR-18a + miR-21 + miR-92a 93.8 62.2 0.828 (0.766, 0.890) 6.884 0.559
miR-18a + miR-21 + miR-199a 81.3 57.3 0.746 (0.672, 0.820) 3.845 0.386
miR-18a + miR-92a + miR-199a 98.8 52.4 0.826 (0.764, 0.888) 6.174 0.512
miR-19a + miR-21 + miR-92a 81.3 72.0 0.859 (0.805, 0.913) 7.140 0.532
miR-19a + miR-21 + miR-199a 80.0 72.0 0.820 (0.756, 0.883) 3.410 0.520
miR-19a + miR-92a + miR-199a 72.5 81.7 0.857 (0.802, 0.912) 7.188 0.542
miR-21 + miR-92a + miR-199a 92.5 62.2 0.820 (0.757, 0.884) 6.830 0.547
miR-18a + miR-19a + miR-21 + miR-92a 82.5 73.2 0.861 (0.807, 0.915) 6.938 0.557
miR-18a + miR-19a + miR-21 + miR-199a 75.0 80.5 0.836 (0.775, 0.897) 4.022 0.555
miR-18a + miR-19a + miR-92a + miR-199a 77.5 79.3 0.861 (0.806, 0.915) 6.876 0.568
miR-18a + miR-21 + miR-92a + miR-199a 97.5 58.5 0.830 (0.768, 0.891) 6.166 0.560
miR-19a + miR-21 + miR-92a + miR-199a 80.0 75.6 0.862 (0.808, 0.915) 6.491 0.556
miR-18a + miR-19a + miR-21 + miR-92a + miR-199a 87.5 69.5 0.867 (0.814, 0.920) 5.983 0.570
  1. The bold font indicates that the P value of every microRNA in the combination was less than 0.05 in the logistic regression
  2. Abbreviation: AUC area under the curve, CI confidence interval