Table 4 Most common AEs occurring in ≥20% of patients
AE, n (%) | Vemurafenib (N = 46) | |
|---|---|---|
Any grade | Grade ≥ 3 | |
At least 1 AE | 46 (100) | 7 (15.2) |
Dermatitis acneiform | 30 (65.2) | 0 |
Arthralgia | 30 (65.2) | 0 |
Blood cholesterol level increase | 27 (58.7) | 1 (2.2) |
Diarrhea | 27 (58.7) | 0 |
Blood bilirubin level increase | 25 (54.3) | 0 |
Melanocytic nevus | 24 (52.2) | 0 |
Alopecia | 23 (50.0) | 0 |
Palmar-plantar erythrodysesthesia syndrome | 22 (47.8) | 0 |
Photosensitivity reaction | 17 (37.0) | 0 |
Fatigue | 14 (30.4) | 0 |
Pyrexia | 13 (28.3) | 0 |
Rash maculopapular | 12 (26.1) | 0 |
γ-glutamyltransferase level increase | 11 (23.9) | 1 (2.2) |
Proteinuria | 11 (23.9) | 0 |
Total bile acid level increase | 10 (21.7) | 0 |
Hypertriglyceridemia | 10 (21.7) | 0 |
Leukopenia | 10 (21.7) | 0 |