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Table 4 Cox univariate analysis for progression-free survival, with a time dependency added to CYFRA 21-1 pre-treatment and post-treatment levels

From: Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy

  Univariate analysis
HR [95%CI] p
Age at diagnosis (> vs. ≤ 65 years) 0.95 [0.39;2.33] 0.91
Gender (male/female) 0.57 [0.17;1.96] 0.47
T stage (T3/T4 vs. T1/T2) 2.65 [1.06;6.34] 0.04
Nodal status (positive/negative) 1.07 [0.44;2.62] 0.88
Clinical stage (IIIA/IIIB vs. I/II) 1.36 [0.52;3.54] 0.53
Chemotherapy associated with radiation therapy (yes/no) 1.02 [0.37;2.8] 0.97
CYFRA 21-1 levels (elevated /normal)
Pre-treatment 2.17 [0.64;7.42] 0.22
Post-treatment 2.64 [1.09;6.36] 0.03