Fig. 2

CTSK expression in OSCC and normal mucosa. Representative stainings of the TMA, consisting of 83 OSCC cases, are presented. CTSK is diffusely expressed, is stained both in tumor as in stromal cells and varies in expression from non to strong expression. Staining scores were calculated by the product of intensity (normal = 1, strong = 2) and the proportion of stained tumor or stromal cells (%). Panels a-f represent examples of CTSK staining; a) normal mucosa, b) OSCC negative for CTSK in stromal cells, c) OSCC with normal staining in tumor cells and in stromal cells, d) OSCC negative for CTSK, e) OSCC with a normal intensity (score = 1 × 50% = 50), f) OSCC with a strong intensity (score = 2 × 75% = 150)