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Fig. 3 | BMC Cancer

Fig. 3

From: The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

Fig. 3

H3F3A mutation causes GCT of the clivus. a Sequence electropherograms of the PCR product of the H3F3A gene, showing the low mutational peak at position c.103 in patient 1 (left) and patient 2 (right). Asterisks denote the mutated base. b Representative electropherogram of patient 1 showing the allele specific sequencing of cloned DNA fragment and demonstrating the presence of p.Gly34Trp mutation in H3F3A. c Immunofluorescent visualization of the H3F3A mutation in the nuclei of mononuclear cells, while osteoclastic giant cells are negative and only react with TRAP antibody (20× objective, scale bar 100 μm). Note the higher number of neoplastic cells in Clival GCT of patient 1 (left) compared to patient 2 (right)

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BMC Cancer

ISSN: 1471-2407

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