Fig. 3
From: Modeling treatment-dependent glioma growth including a dormant tumor cell subpopulation
Impact of cyclic treatment on the cell population. In each treatment interval, either high dosage (H) or low dosage (L) treatment is applied.Top: Population composition between dormant (D) and rapidly proliferating (P) cells displayed by the relative fraction of both phenotypes under changing conditions. Middle panel: Average growth rate of the whole population under changing treatment condition. A negative growth rate only occurs in phases of strong treatment. Bottom panel: Absolute number of all tumor cells, P and D phenotype, assuming exponential growth with the given average growth rate (parameters: dormant cell growth rate ε = 0, conversion rate σ = 0.01, high dosage effect λ H = 1, low dosage effect λ L = 0.25)