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Table 5 The activation/suppression status of the lymphocytes of the primary tumor and the metastatic tumor

From: A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study

  Primary tumor Metastatic tumor
PD-1
 Median (range) 1.8 (0–8.4) 1.3 (0–11.2)
CTLA4
 Median (range) 1.0 (0–5.4) 0.4 (0–2.0)
ICOS
 Median (range) 3.0 (0–12.4) 2.6 (0.2–9.0)
GITR
 Median (range) 0.9 (0–6.6) 0.4 (0–3.8)
HLA-DR
 Median (range) 0.6 (0–3.0) 0.4 (0–2.2)
Granzyme B
 Median (range) 1.2 (0.4–4.4) 1.0 (0–2.8)
The PD-1/CD8 ratio
 Median (range) 0.32 (0–10.5) 0.41 (0–15.0)
The FOXP3/CD4 ratio
 Median (range) 0.79 (0–11.5) 0.86 (0.2–12.5)
  1. PD-1 Programmed cell death 1, CTLA4 cytotoxic T-lymphocyte-associated protein 4, ICOS inducible T-cell co-stimulator, GITR Glucocorticoid induced tumor necrosis factor receptor related protein, HLA-DR Human Leukocyte Antigen - antigen D Related, FOXP3 Forkhead boxprotein P3