Table 5 The activation/suppression status of the lymphocytes of the primary tumor and the metastatic tumor
| Â | Primary tumor | Metastatic tumor |
|---|---|---|
PD-1 | ||
 Median (range) | 1.8 (0–8.4) | 1.3 (0–11.2) |
CTLA4 | ||
 Median (range) | 1.0 (0–5.4) | 0.4 (0–2.0) |
ICOS | ||
 Median (range) | 3.0 (0–12.4) | 2.6 (0.2–9.0) |
GITR | ||
 Median (range) | 0.9 (0–6.6) | 0.4 (0–3.8) |
HLA-DR | ||
 Median (range) | 0.6 (0–3.0) | 0.4 (0–2.2) |
Granzyme B | ||
 Median (range) | 1.2 (0.4–4.4) | 1.0 (0–2.8) |
The PD-1/CD8 ratio | ||
 Median (range) | 0.32 (0–10.5) | 0.41 (0–15.0) |
The FOXP3/CD4 ratio | ||
 Median (range) | 0.79 (0–11.5) | 0.86 (0.2–12.5) |