Impact of a behaviorally-based weight loss intervention on parameters of insulin resistance in breast cancer survivors

Table 4 Analysis of covariance of insulin parameter changes, adjusted by age and baseline BMI, by weight loss group

	< 5% (n = 20)		≥5% (n = 31)		p
	Baseline	6 Months	Baseline	6 Months	p
Fasting glucose (M ± SD)	94.05 ± 6.73	93.72 ± 7.89	93.40 ± 10.33	96.22 ± 14.46	0.328
Fasting insulin (M ± SD)	8.54 ± 4.12	10.72 ± 6.73	9.88 ± 7.08	6.96 ± 4.40	0.005
AUC glucose (M ± SD)	7956.75 ± 3140.77	8079.25 ± 3267.80	6883.71 ± 3389.54	6542.26 ± 3720.90	0.261
AUC insulin (M ± SD)	6756.94 ± 2422.85	7248.23 ± 2176.00	8009.73 ± 4362.87	6586.39 ± 4579.06	0.026
30-min insulin (M ± SD)	45.87 ± 23.37	55.63 ± 33.42	58.38 ± 34.42	48.08 ± 35.09	0.039
HOMA-IR (%) (M ± SD)	1.17 ± 0.49	1.39 ± 0.84	1.36 ± 0.91	0.97 ± 0.58	< 0.001
HOMA-B (%) (M ± SD)	95.28 ± 27.88	106.74 ± 46.13	105.94 ± 41.44	85.17 ± 33.57	0.011
Matsuda index (insulin sensitivity) (M ± SD)	4.14 ± 1.30	3.64 ± 1.20	4.70 ± 2.79	5.87 ± 2.92	0.001
Leptin (ng/mL) (M ± SD)	50.07 ± 24.02	46.31 ± 23.54	40.17 ± 16.47	23.09 ± 15.23	< 0.001
Adiponectin (mcg/mL) (M ± SD)	10.86 ± 40.65	10.82 ± 45.13	13.18 ± 5.36	13.19 ± 5.07	0.319
Leptin/Adiponectin (M ± SD)	4.92 ± 2.18	4.53 ± 1.76	3.94 ± 2.94	2.17 ± 1.89	< 0.001

The p-value refers to the association of weight loss group with the 6-month measure, when the baseline measure, age and baseline BMI are included in the model. HOMA-IR (%) was logit-transformed prior to analysis of covariance. Analysis of covariance of the Matsuda index was
HOMA-IR – estimate of insulin resistance
HOMA-B – estimate of beta cell function

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